Mystery of Expansion: DNA Metabolism and Unstable Repeats.
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DOI: 10.1007/978-3-030-41283-8_7
Abstract: The mammalian genome mostly contains repeated sequences. Some of these repeats are in the regulatory elements of genes, and their instability, particularly the propensity to change the repeat unit number, is responsible for 36 well-known… read more here.
Keywords: dna metabolism; expansion; metabolism; expansion dna ... See more keywords
Chaperoning RPA during DNA metabolism
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DOI: 10.1007/s00294-019-00945-3
Abstract: Single-stranded DNA (ssDNA) is widely generated during DNA metabolisms including DNA replication, repair and recombination and is susceptible to digestion by nucleases and secondary structure formation. It is vital for DNA metabolism and genome stability… read more here.
Keywords: dna metabolism; dna; ssdna; replication ... See more keywords
Unravelling How Single-Stranded DNA Binding Protein Coordinates DNA Metabolism Using Single-Molecule Approaches
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DOI: 10.3390/ijms24032806
Abstract: Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double helix from re-annealing and maintaining genome integrity. In the meantime,… read more here.
Keywords: dna metabolism; single molecule; dna; protein ... See more keywords