Differential regulation of the DNA methylome in adults born during the Great Chinese Famine in 1959-1961.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.09.018
Abstract: BACKGROUND Extensive epidemiological studies have established the association between exposure to early-life adversity and health status and diseases in adults. Epigenetic regulation is considered as a key mediator for this phenomenon but analysis on humans… read more here.
Keywords: great chinese; adults born; dna methylome; famine ... See more keywords
DNA methylome profiling of circulating tumor cells in lung cancer at single base-pair resolution
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01657-0
Abstract: DNA methylation plays a pivotal role in regulating cellular processes, and altered DNA methylation pattern is a general hallmark of cancer. However, DNA methylome in circulating tumor cells (CTCs) is still a mystery due to… read more here.
Keywords: dna methylation; dna methylome; lung cancer; dna ... See more keywords
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
Sign Up to like & getrecommendations! Published in 2018 at "Translational Psychiatry"
DOI: 10.1038/s41398-017-0063-9
Abstract: This study reveals the influence of child maltreatment on DNA methylation across the genome and provides the first evidence that a psychosocial intervention program, the Nurse Family Partnership (NFP), which targets mothers at risk for… read more here.
Keywords: dna methylome; dna; methylome variation; program ... See more keywords
DNA methylome and transcriptome landscapes revealed differential characteristics of dioecious flowers in papaya
Sign Up to like & getrecommendations! Published in 2020 at "Horticulture Research"
DOI: 10.1038/s41438-020-0298-0
Abstract: Separate sexes in dioecious plants display different morphology and physiological characteristics. The differences between the two sexes lie in their highly differentiated floral characteristics and in sex-related phenotype, which is genetically determined and epigenetically modified.… read more here.
Keywords: methylation; methylome transcriptome; dna methylome; transcriptome landscapes ... See more keywords
Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01586-1
Abstract: Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic… read more here.
Keywords: dna methylome; dna; disease; dna methylation ... See more keywords
The DNA methylome of cervical cells can predict the presence of ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-26615-y
Abstract: The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived cervical cells from women with… read more here.
Keywords: cancer; dna methylome; cervical cells; ovarian cancer ... See more keywords
Global misregulation of genes largely uncoupled to DNA methylome epimutations characterizes a congenital overgrowth syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13012-z
Abstract: Assisted reproductive therapies (ART) have become increasingly common worldwide and numerous retrospective studies have indicated that ART-conceived children are more likely to develop the overgrowth syndrome Beckwith-Wiedemann (BWS). In bovine, the use of ART can… read more here.
Keywords: methylome epimutations; overgrowth syndrome; dna methylome; misregulation ... See more keywords
DNA methylome analysis reveals distinct epigenetic patterns of ascending aortic dissection and bicuspid aortic valve
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvx050
Abstract: Aims Epigenetics may mediate the effects of environmental risk factors on disease, including heart disease. Thus, measuring the DNA methylome offers the opportunity to identify novel disease biomarkers and novel insights into disease mechanisms. The… read more here.
Keywords: analysis reveals; methylation; dna methylome; dna ... See more keywords
DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.04.11.487909
Abstract: Aberrant DNA methylation is a well-known feature of tumours and has been associated with metastatic melanoma. However, since melanoma cells are highly heterogeneous, it has been challenging to use affected genes to predict tumour aggressiveness,… read more here.
Keywords: cell; melanoma; cluster oriented; dna methylome ... See more keywords
Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction
Sign Up to like & getrecommendations! Published in 2018 at "Aging Cell"
DOI: 10.1111/acel.12738
Abstract: Aging is characterized by numerous molecular changes, such as accumulation of molecular damage and altered gene expression, many of which are linked to DNA methylation. Here, we characterize the blood DNA methylome across 16 age… read more here.
Keywords: methylation; dna methylome; calorie restriction; dna ... See more keywords
DNA methylome profiling identifies novel methylated genes in epithelial ovarian cancer patients with platinum resistance
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.14634
Abstract: Platinum‐based chemotherapy is widely used for epithelial ovarian cancer (EOC). As high as 20–25% of EOC patients will not respond to the initial chemotherapy. Accumulated evidences have implied that DNA methylation may serve as a… read more here.
Keywords: platinum resistance; dna methylome; epithelial ovarian; ovarian cancer ... See more keywords