Epigenetic and metabolic alterations in human amniotic fluid stem cells induced to cardiomyogenic differentiation by DNA methyltransferases and p53 inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28092
Abstract: Human amniotic fluid‐derived mesenchymal stem cells (AF‐MSCs) may be a valuable source for cell therapy and regenerative medicine. In this study, the potential of DNA methyltransferases (DNMT) inhibitors Decitabine, Zebularine, RG108 alone or combined with… read more here.
Keywords: cardiomyogenic differentiation; dna methyltransferases; differentiation; human amniotic ... See more keywords
Association analysis of DNA methyltransferases in IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.106147
Abstract: DNA methylation, especially DNA methyltransferases (DNMTs), is involved in the pathogenesis of many autoimmune diseases through regulating immune function. This study aimed to explore the potential role of DNMTs in IgA nephropathy (IgAN). We evaluated… read more here.
Keywords: igan patients; association analysis; iga nephropathy; dna methyltransferases ... See more keywords
Ultrasensitive and Label-Free Detection of Multiple DNA Methyltransferases by Asymmetric Nanopore Biosensor.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c05332
Abstract: DNA methylation is catalyzed by a family of DNA methyltransferases that play crucial roles in various biological processes. Therefore, an ultrasensitive methyltransferase assay is highly desirable in biomedical research and clinical diagnosis. However, conventional assays… read more here.
Keywords: label free; dna; methyltransferase; ultrasensitive label ... See more keywords
Actinobacillus pleuropneumoniae encodes multiple phase-variable DNA methyltransferases that control distinct phasevarions
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad091
Abstract: Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumonia, a severe respiratory tract infection that is responsible for major economic losses to the swine industry. Many host-adapted bacterial pathogens encode systems known as phasevarions (phase- variable… read more here.
Keywords: dna; type iii; actinobacillus pleuropneumoniae; phase ... See more keywords
Role of Mammalian DNA Methyltransferases in Development.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-103019-102815
Abstract: DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the two DNMT families, DNMT3 and DNMT1, are responsible for methylation establishment… read more here.
Keywords: biochemistry; methylation; dna; dna methyltransferases ... See more keywords
Role of DNA Methyltransferases (DNMTs) in metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2022.68.1.27
Abstract: The DNA methyltransferase (DNMT) family constitutes a conserved set of DNA-modifying enzymes which have essential functions in the modulation of epigenetics. The fundamental role of epigenetic changes in carcinogenesis and metastasis is increasingly being appreciated.… read more here.
Keywords: metastasis; dna; dnmts metastasis; dna methyltransferases ... See more keywords
Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells that Are Defective in Self-Renewal
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc22138
Abstract: Background and Objectives DNA methyltransferases (Dnmts) play an important role in regulating DNA methylation during early developmental processes and cellular differentiation. In this study, we aimed to investigate the role of Dnmts in neural differentiation… read more here.
Keywords: embryonic stem; neural stem; self renewal; stem ... See more keywords
Diversity of Fungal DNA Methyltransferases and Their Association With DNA Methylation Patterns
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.616922
Abstract: DNA methyltransferases (DNMTs) are a group of proteins that catalyze DNA methylation by transferring a methyl group to DNA. The genetic variation in DNMTs results in differential DNA methylation patterns associated with various biological processes.… read more here.
Keywords: methylation; dna methyltransferases; dnmts; methylation patterns ... See more keywords
Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00332
Abstract: Traditionally, neuroscience has had to rely on mixed tissue analysis to examine transcriptional and epigenetic changes in the context of nervous system function or pathology. However, particularly when studying chronic pain conditions, this approach can… read more here.
Keywords: dnmt3a; dna methyltransferases; negative evidence; role neuronal ... See more keywords
Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01144
Abstract: Naturally occurring small molecules include a large variety of natural products from different sources that have confirmed activity against epigenetic targets. In this work we review chemoinformatic, molecular modeling, and other computational approaches that have… read more here.
Keywords: methyltransferases natural; dna methyltransferases; natural sources; sources computational ... See more keywords
The interplay of DNA methyltransferases and demethylases with tuberization genes in potato (Solanum tuberosum L.) genotypes under high temperature
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.933740
Abstract: Potato is a temperate crop consumed globally as a staple food. High temperature negatively impacts the tuberization process, eventually affecting crop yield. DNA methylation plays an important role in various developmental and physiological processes in… read more here.
Keywords: genotypes high; tuberization; temperature; high temperature ... See more keywords