Multiple zinc ions maintain the open conformation of the catalytic site in the DNA mismatch repair endonuclease MutL from Aquifex aeolicus
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13050
Abstract: The DNA mismatch repair endonuclease MutL consists of N‐terminal ATPase and C‐terminal endonuclease domains. The endonuclease domain binds zinc ion, although the ion seems not to function as a catalytic metal ion. Here, we solved… read more here.
Keywords: endonuclease; dna mismatch; zinc; mutl ... See more keywords
Expanded roles for the MutL family of DNA mismatch repair proteins
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DOI: 10.1002/yea.3512
Abstract: The MutL family of DNA mismatch repair proteins plays a critical role in excising and repairing misincorporation errors during DNA replication. In many eukaryotes, members of this family have evolved to modulate and resolve recombination… read more here.
Keywords: mutl family; mismatch repair; family; dna mismatch ... See more keywords
A loss-of-function variant in DNA mismatch repair gene MLH3 underlies severe oligozoospermia.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of human genetics"
DOI: 10.1038/s10038-021-00907-z
Abstract: Male infertility pertains to male's inability to cause pregnancy in a fertile female. It accounts for 40-50% of infertility in human. In the study, presented here, a large consanguineous family of Pakistani origin segregating male… read more here.
Keywords: mlh3; dna mismatch; mismatch repair; male infertility ... See more keywords
Examination of gene loss in the DNA mismatch repair pathway and its mutational consequences in a fungal phylum.
Sign Up to like & getrecommendations! Published in 2021 at "Genome biology and evolution"
DOI: 10.1093/gbe/evab219
Abstract: The DNA mismatch repair (MMR) pathway corrects mismatched bases produced during DNA replication and is highly conserved across the tree of life, reflecting its fundamental importance for genome integrity. Loss of function in one or… read more here.
Keywords: dna mismatch; mmr pathway; mismatch repair; gene loss ... See more keywords
Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad015
Abstract: Abstract The DNA mismatch repair protein MutSα recognizes wrongly incorporated DNA bases and initiates their correction during DNA replication. Dysfunctions in mismatch repair lead to a predisposition to cancer. Here, we study the homozygous mutation… read more here.
Keywords: mismatch binding; affinity dna; dna; high affinity ... See more keywords
A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad418
Abstract: DNA mismatch repair (MMR) is essential for correction of DNA replication errors. Germline mutations of the human MMR gene MLH1 are the major cause of Lynch syndrome, a heritable cancer predisposition. In the MLH1 protein,… read more here.
Keywords: mlh1; dna mismatch; mismatch repair; repair ... See more keywords
Evolutionary advantage of a dissociative search mechanism in DNA mismatch repair.
Sign Up to like & getrecommendations! Published in 2021 at "Physical review. E"
DOI: 10.1103/physreve.103.052404
Abstract: Protein complexes involved in DNA mismatch repair diffuse along dsDNA as sliding clamps in order to locate a hemimethylated incision site. They have been observed to use a dissociative mechanism, in which two proteins, while… read more here.
Keywords: search mechanism; dna mismatch; mechanism; search ... See more keywords
Prognostic and predictive role of DNA mismatch repair status in stage II‐III colorectal cancer: A systematic review and meta‐analysis
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DOI: 10.1111/cge.13628
Abstract: DNA mismatch repair (MMR) status was considered to be a potential prognostic factor for colorectal cancer (CRC) but with conflicting reports, and varied in terms of TNM stages. Its relationship with prognosis in stage II‐III… read more here.
Keywords: status; stage iii; dna mismatch; colorectal cancer ... See more keywords
DNA mismatch repair protein immunohistochemistry – an illustrated guide
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DOI: 10.1111/his.14367
Abstract: DNA mismatch repair (MMR) is an essential physiological process for correcting mutations occurring during DNA replication. Deficient MMR (dMMR) leads to increased tumour mutational burden, with a heightened risk of neoplasia. Demonstration of dMMR via… read more here.
Keywords: mismatch repair; guide dna; illustrated guide; dna mismatch ... See more keywords
Vaccines for immunoprevention of DNA mismatch repair deficient cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004416
Abstract: The development of cancer vaccines to induce tumor-antigen specific immune responses was sparked by the identification of antigens specific to or overexpressed in cancer cells. However, weak immunogenicity and the mutational heterogeneity in many cancers… read more here.
Keywords: cancer; dna mismatch; mismatch repair; lynch syndrome ... See more keywords
MEX3A impairs DNA mismatch repair signaling and mediates acquired temozolomide resistance in glioblastoma.
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DOI: 10.1158/0008-5472.can-22-2036
Abstract: MutS protein homolog 2 (MSH2) is a key element involved in the DNA mismatch repair system, which is responsible for recognizing and repairing mispaired bases. Simultaneously, MSH2 identifies DNA adducts induced by temozolomide (TMZ) and… read more here.
Keywords: mismatch repair; dna mismatch; msh2; mex3a ... See more keywords