Detection of Low-Abundance DNA Modifications Using Signal Amplification-Based Immunocytochemistry.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0876-0_14
Abstract: Immunocytochemistry can be instrumental in assessing the spatial distribution and relative levels of epigenetic modifications. Although conventional immunostaining has been utilized for the detection of 5-methylcytosine (5mC) in animal cells and tissues for several decades,… read more here.
Keywords: dna; immunocytochemistry; detection low; low abundance ... See more keywords
Evidence for Noncytosine Epigenetic DNA Modifications in Multicellular Eukaryotes: An Overview.
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DOI: 10.1007/978-1-0716-0876-0_2
Abstract: Cytosine DNA methylation (5-methylcytsone, 5mC) is the major DNA modification found in the genomes of animals and plants. Although the roles of 5mC and its oxidized derivatives in the regulation of gene expression are relatively… read more here.
Keywords: epigenetic dna; dna; evidence noncytosine; noncytosine epigenetic ... See more keywords
Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tandem Mass Spectrometry (2D-UPLC-MS/MS).
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0876-0_8
Abstract: Our hereby presented methodology is suitable for reliable assessment of the most common DNA modifications which arise as a product of fundamental metabolic processes. 8-oxoguanine, one of the oxidatively modified DNA bases is a typical… read more here.
Keywords: dna; dimensional ultraperformance; two dimensional; liquid chromatography ... See more keywords
Drug Addiction and DNA Modifications.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-53889-1_6
Abstract: Drug addiction is a complex disorder which can be influenced by both genetic and environmental factors. Research has shown that epigenetic modifications can translate environmental signals into changes in gene expression, suggesting that epigenetic changes… read more here.
Keywords: addiction; drug; epigenetic changes; drug addiction ... See more keywords
DNA-MP: a generalized DNA modifications predictor for multiple species based on powerful sequence encoding method
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac546
Abstract: Accurate prediction of deoxyribonucleic acid (DNA) modifications is essential to explore and discern the process of cell differentiation, gene expression and epigenetic regulation. Several computational approaches have been proposed for particular type-specific DNA modification prediction.… read more here.
Keywords: dna modifications; multiple species; dna; sequence encoding ... See more keywords
DNA Modifications Enabling Proximity Biotinylation
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate Chemistry"
DOI: 10.1101/2022.10.02.510503
Abstract: Advances in peroxidase- and biotin ligase-mediated signal amplification have enabled high-resolution subcellular mapping of endogenous RNA localization and protein-protein interactions. Application of these technologies has been limited to RNA and proteins because of the reactive… read more here.
Keywords: dna modifications; modifications enabling; proximity biotinylation; biotinylation ... See more keywords
Invited Review – A 5‐year update on epigenome‐wide association studies of DNA modifications in Alzheimer’s disease: progress, practicalities and promise
Sign Up to like & getrecommendations! Published in 2020 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12650
Abstract: In late 2014, the first epigenome‐wide association studies of DNA modifications in Alzheimer’s disease brain samples were published. Over the last 5 years, further studies have been reported in the field and have highlighted consistent… read more here.
Keywords: epigenome wide; alzheimer disease; disease; studies dna ... See more keywords