Lipid‐Polymer Hybrid “Particle‐in‐Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID‐19 Vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202204462
Abstract: SARS‐CoV‐2 has led to a worldwide pandemic, catastrophically impacting public health and the global economy. Herein, a new class of lipid‐modified polymer poly (β‐amino esters) (L‐PBAEs) is developed via enzyme‐catalyzed esterification and further formulation of… read more here.
Keywords: dna mrna; pnp; particle; gene ... See more keywords
A Universal GSH-Responsive Nanoplatform for the Delivery of DNA, mRNA, and Cas9/sgRNA Ribonucleoprotein.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b03496
Abstract: The long-sought promise of gene therapy for the treatment of human diseases remains unfulfilled, largely hindered by the lack of an efficient and safe delivery vehicle. In this study, we have developed a universal glutathione-responsive… read more here.
Keywords: dna mrna; dna; mrna cas9; cas9 sgrna ... See more keywords
DNA and mRNA Vaccines for Chronic Viral Infections and Cancer: Rationale, Mechanisms, and Progress
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DOI: 10.3390/cancers14235874
Abstract: Simple Summary This review describes the rationale supporting the use of DNA and mRNA vaccines as immunotherapeutic vaccines for treating chronic viral infections and cancer. It specifically focuses on the immunological challenges for generating potent… read more here.
Keywords: mrna vaccines; dna mrna; viral infections; chronic viral ... See more keywords