Conformational enhancement of fidelity in toehold-sequestered DNA nanodevices.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc00882f
Abstract: The operation of DNA nanodevices is often limited by erroneous strand displacement. Here we demonstrate simple design principles that reduce such leakage by up to two orders of magnitude. Enhanced operational robustness against multiple spurious… read more here.
Keywords: sequestered dna; toehold sequestered; enhancement fidelity; conformational enhancement ... See more keywords
Subcellular localization of DNA nanodevices and their applications.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06017e
Abstract: The application of nanodevices based on DNA self-assembly in the field of cell biology has made significant progress in the past decade. In this study, the development of DNA nanotechnology is briefly reviewed. The subcellular… read more here.
Keywords: subcellular localization; dna; nanodevices applications; localization dna ... See more keywords
A versatile and convenient tool for regulation of DNA strand displacement and post-modification on pre-fabricated DNA nanodevices
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1193
Abstract: Abstract Toehold-mediated strand displacement and its regulatory tools are fundamental for DNA nanotechnology. However, current regulatory tools all need to change the original sequence of reactants, making the regulation inconvenient and cumbersome. More importantly, the… read more here.
Keywords: dna; nanotechnology; post modification; regulation ... See more keywords
Tissue-specific targeting of DNA nanodevices in a multicellular living organism
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.67830
Abstract: Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease targets that need corrective action are localized in specific organs, and thus realizing… read more here.
Keywords: organism; tissue specific; dna; biology ... See more keywords