DNA G-Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10656
Abstract: G-quadruplexes (G4s) are four-stranded DNA secondary structures that occur in the human genome and play key roles in transcription, replication, and genome stability. G4-specific molecular probes are of vital importance to elucidate the structure and… read more here.
Keywords: dna quadruplex; structure; live cells; quadruplex recognition ... See more keywords
Encoding canonical DNA quadruplex structure
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DOI: 10.1126/sciadv.aat3007
Abstract: The remarkable architectural diversity of four-stranded DNA known as G-quadruplexes can be rationally designed. The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its multiple, repetitive… read more here.
Keywords: encoding canonical; quadruplex structure; dna quadruplex; dna ... See more keywords
Abstract 2662: Indenoisoquinoline topoisomerase I inhibitors target the DNA G-quadruplex formed in the c-Myc promoter and cause MYC downregulation
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2662
Abstract: The inhibition of DNA topoisomerase I (Top1) has proven to be a successful approach toward the design of anticancer agents. Indenoisoquinoline derivatives have been designed and developed as Top1 inhibitors and can overcome some shortcomings… read more here.
Keywords: quadruplex formed; dna quadruplex; promoter; myc downregulation ... See more keywords