Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G‐Quadruplexes
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DOI: 10.1002/cbic.202000136
Abstract: Infrared spectroscopy detects the formation of G‐quadruplexes in guanine‐rich nucleic acid sequences through shifts in the guanine C=O stretch mode. Here, we use ultrafast 2D infrared (IR) spectroscopy and isotope substitution to show that these… read more here.
Keywords: infrared spectroscopy; dna quadruplexes; disorder; parallel stranded ... See more keywords
Engineering DNA quadruplexes in DNA nanostructures for biosensor construction
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DOI: 10.1007/s12274-021-3869-y
Abstract: DNA quadruplexes are nucleic acid conformations comprised of four strands. They are prevalent in human genomes and increasing efforts are being directed toward their engineering. Taking advantage of the programmability of Watson-Crick base-pairing and conjugation… read more here.
Keywords: dna; construction; dna quadruplexes; dna nanostructures ... See more keywords
Conformational Dynamics of Strand Register Shifts in DNA G-quadruplexes.
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DOI: 10.1021/jacs.9b10367
Abstract: The complex folding energy landscape of DNA G-quadruplexes leads to numerous conformations for this functionally important class of non-canonical DNA structures. A new layer of conformational heterogeneity comes from sequences with different numbers of G-nucleotides… read more here.
Keywords: conformational dynamics; dna; dna quadruplexes; dynamics strand ... See more keywords
Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells
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DOI: 10.1080/14756366.2023.2198678
Abstract: Abstract Some metallo-supramolecular helical assemblies with size, shape, charge and amphipathic architectures similar to short cationic α-helical peptides have been shown to target and stabilise DNA G-quadruplexes (G4s) in vitro and downregulate the expression of… read more here.
Keywords: asymmetric triplex; dna; dna quadruplexes; stabilise dna ... See more keywords
Epigenomic Features and Potential Functions of K+ and Na+ Favorable DNA G-Quadruplexes in Rice
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DOI: 10.3390/ijms23158404
Abstract: DNA G-quadruplexes (G4s) are non-canonical four-stranded DNA structures involved in various biological processes in eukaryotes. Molecularly crowded solutions and monovalent cations have been reported to stabilize in vitro and in vivo G4 formation. However, how… read more here.
Keywords: dna; dna quadruplexes; specific g4s; features potential ... See more keywords