Functional Disruption of Gli1‐DNA Recognition via a Cobalt(III) Complex
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DOI: 10.1002/cmdc.202200025
Abstract: The aberrant activation of the Gli family of zinc finger transcription factors (ZFTFs) is associated with several types of human cancer, including medulloblastoma and basal cell carcinoma. We have reported the use of cobalt(III) Schiff‐base… read more here.
Keywords: dna; cobalt iii; gli1; dna recognition ... See more keywords
Bacterial DNA Recognition by SERS Active Plasma-Coupled Nanogold
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DOI: 10.1021/acs.nanolett.2c02835
Abstract: It is shown that surface-enhanced Raman spectroscopy (SERS) can identify bacteria based on their genomic DNA composition, acting as a “sample-distinguishing marker”. Successful spectral differentiation of bacterial species was accomplished with nanogold aggregates synthesized through… read more here.
Keywords: dna; recognition sers; dna recognition; sers active ... See more keywords
DNA mismatches reveal conformational penalties in protein-DNA recognition
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DOI: 10.1038/s41586-020-2843-2
Abstract: Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects… read more here.
Keywords: transcription; dna recognition; dna; protein dna ... See more keywords
Xenogeneic Silencing and Bacterial Genome Evolution: Mechanisms for DNA Recognition Imply Multifaceted Roles of Xenogeneic Silencers
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab136
Abstract: Abstract Horizontal gene transfer (HGT) is a major driving force for bacterial evolution. To avoid the deleterious effects due to the unregulated expression of newly acquired foreign genes, bacteria have evolved specific proteins named xenogeneic… read more here.
Keywords: multifaceted roles; dna recognition; evolution; xenogeneic silencers ... See more keywords
Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz113
Abstract: Abstract In rice, the critical regulator of the salicylic acid signalling pathway is OsWRKY45, a transcription factor (TF) of the WRKY TF family that functions by binding to the W-box of gene promoters, but the… read more here.
Keywords: dna recognition; dna; wrky; box ... See more keywords
Structural basis for DNA recognition by FOXC2.
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.2210/pdb6akp/pdb
Abstract: The FOXC family of transcription factors (FOXC1 and FOXC2) plays essential roles in the regulation of embryonic, ocular, and cardiac development. Mutations and abnormal expression of FOXC proteins are implicated in genetic diseases as well… read more here.
Keywords: structural basis; dna recognition; basis dna; dna ... See more keywords
Cognate DNA Recognition by Engrailed Homeodomain Involves A Conformational Change Controlled via An Electrostatic-Spring-Loaded Latch
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DOI: 10.3390/ijms23052412
Abstract: Transcription factors must scan genomic DNA, recognize the cognate sequence of their control element(s), and bind tightly to them. The DNA recognition process is primarily carried out by their DNA binding domains (DBD), which interact… read more here.
Keywords: cognate dna; dna; cognate; dna recognition ... See more keywords