Functional Disruption of Gli1‐DNA Recognition via a Cobalt(III) Complex
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200025
Abstract: The aberrant activation of the Gli family of zinc finger transcription factors (ZFTFs) is associated with several types of human cancer, including medulloblastoma and basal cell carcinoma. We have reported the use of cobalt(III) Schiff‐base… read more here.
Keywords: dna; cobalt iii; gli1; dna recognition ... See more keywords
Bacterial DNA Recognition by SERS Active Plasma-Coupled Nanogold
Sign Up to like & getrecommendations! Published in 2022 at "Nano Letters"
DOI: 10.1021/acs.nanolett.2c02835
Abstract: It is shown that surface-enhanced Raman spectroscopy (SERS) can identify bacteria based on their genomic DNA composition, acting as a “sample-distinguishing marker”. Successful spectral differentiation of bacterial species was accomplished with nanogold aggregates synthesized through… read more here.
Keywords: dna; recognition sers; dna recognition; sers active ... See more keywords
DNA mismatches reveal conformational penalties in protein-DNA recognition
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2843-2
Abstract: Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects… read more here.
Keywords: transcription; dna recognition; dna; protein dna ... See more keywords
Xenogeneic Silencing and Bacterial Genome Evolution: Mechanisms for DNA Recognition Imply Multifaceted Roles of Xenogeneic Silencers
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab136
Abstract: Abstract Horizontal gene transfer (HGT) is a major driving force for bacterial evolution. To avoid the deleterious effects due to the unregulated expression of newly acquired foreign genes, bacteria have evolved specific proteins named xenogeneic… read more here.
Keywords: multifaceted roles; dna recognition; evolution; xenogeneic silencers ... See more keywords
Skipping events impose repeated binding attempts: profound kinetic implications of protein–DNA conformational changes
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae333
Abstract: Abstract The kinetics of protein–DNA recognition, along with its thermodynamic properties, including affinity and specificity, play a central role in shaping biological function. Protein–DNA recognition kinetics are characterized by two key elements: the time taken… read more here.
Keywords: dna; dna recognition; skipping events; protein dna ... See more keywords
Structural basis of DNA recognition by BEN domain proteins reveals a role for oligomerization in unmethylated DNA selection by BANP
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae762
Abstract: Abstract The BEN domain is a newly discovered type of DNA-binding domain that exists in a variety of species. There are nine BEN domain-containing proteins in humans, and most have been shown to have chromatin-related… read more here.
Keywords: dna recognition; banp; ben domain; dna ... See more keywords
Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz113
Abstract: Abstract In rice, the critical regulator of the salicylic acid signalling pathway is OsWRKY45, a transcription factor (TF) of the WRKY TF family that functions by binding to the W-box of gene promoters, but the… read more here.
Keywords: dna recognition; dna; wrky; box ... See more keywords
Molecular Insights into DNA Recognition by HD-Zip Transcription Factors.
Sign Up to like & getrecommendations! Published in 2025 at "Plant physiology"
DOI: 10.1093/plphys/kiaf292
Abstract: Homeodomain-leucine zipper (HD-Zip) genes encode a large family of plant-specific transcription factors (TFs) that are integral to plant development, growth, regulation, and responses to environmental and hormonal signals. While the roles and mechanisms of HD-Zip… read more here.
Keywords: dna recognition; transcription factors; zip; dna ... See more keywords
Structural basis for DNA recognition by FOXC2.
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.2210/pdb6akp/pdb
Abstract: The FOXC family of transcription factors (FOXC1 and FOXC2) plays essential roles in the regulation of embryonic, ocular, and cardiac development. Mutations and abnormal expression of FOXC proteins are implicated in genetic diseases as well… read more here.
Keywords: structural basis; dna recognition; basis dna; dna ... See more keywords
DNA recognition using Novel Deep Learning Model
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Electronics and Telecommunications"
DOI: 10.24425/ijet.2024.149569
Abstract: DNA, a significant physiological biometric, is present in all human cells like hair, blood, and skin. This research introduces a new approach called the Deep DNA Learning Network (DDLN) for person identification based on their… read more here.
Keywords: deep learning; dna recognition; learning model; model ... See more keywords
Cognate DNA Recognition by Engrailed Homeodomain Involves A Conformational Change Controlled via An Electrostatic-Spring-Loaded Latch
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052412
Abstract: Transcription factors must scan genomic DNA, recognize the cognate sequence of their control element(s), and bind tightly to them. The DNA recognition process is primarily carried out by their DNA binding domains (DBD), which interact… read more here.
Keywords: cognate dna; dna; cognate; dna recognition ... See more keywords