Prediction of Overall Survival Among Female Patients With Breast Cancer Using a Prognostic Signature Based on 8 DNA Repair–Related Genes
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.14622
Abstract: Key Points Question Can a better prognosis model based on DNA repair–related genes be developed for the comprehensive evaluation of breast cancer? Findings In this prognostic study based on samples from 1096 women, a novel… read more here.
Keywords: dna repair; breast cancer; repair related; related genes ... See more keywords
Exploiting DNA repair defects in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12467
Abstract: Colorectal cancer (CRC) is the third leading cause of cancer‐related deaths worldwide. Therapies that take advantage of defects in DNA repair pathways have been explored in the context of breast, ovarian, and other tumor types,… read more here.
Keywords: dna repair; colorectal cancer; repair defects; exploiting dna ... See more keywords
DNA repair as a shared hallmark in cancer and ageing
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13285
Abstract: Increasing evidence demonstrates that DNA damage and genome instability play a crucial role in ageing. Mammalian cells have developed a wide range of complex and well‐orchestrated DNA repair pathways to respond to and resolve many… read more here.
Keywords: dna repair; shared hallmark; repair shared; cancer ... See more keywords
Corrigendum to: Robust DNA repair in PAXX‐deficient mammalian cells
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12776
Abstract: [This corrects the article DOI: 10.1002/2211-5463.12380.]. read more here.
Keywords: dna repair; deficient mammalian; corrigendum robust; paxx deficient ... See more keywords
Joining the PARty: PARP Regulation of KDM5A during DNA Repair (and Transcription?)
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DOI: 10.1002/bies.202200015
Abstract: The lysine demethylase KDM5A collaborates with PARP1 and the histone variant macroH2A1.2 to modulate chromatin to promote DNA repair. Indeed, KDM5A engages poly(ADP‐ribose) (PAR) chains at damage sites through a previously uncharacterized coiled‐coil domain, a… read more here.
Keywords: dna repair; dna; transcription; regulation ... See more keywords
Surface imprinted bio‐nanocomposites for affinity separation of a cellular DNA repair protein
Sign Up to like & getrecommendations! Published in 2023 at "Biopolymers"
DOI: 10.1002/bip.23537
Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional DNA repair protein localized in different subcellular compartments. The mechanisms responsible for the highly regulated subcellular localization and “interactomes” of this protein are not fully understood but have… read more here.
Keywords: dna repair; repair protein; bio nanocomposite;
Microarray and in silico analysis of DNA repair genes between human testis of patients with nonobstructive azoospermia and normal cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3747
Abstract: DNA repair processes are critical to maintaining genomic integrity. As a result, dysregulation of repair genes is likely to be linked with health implications, such as an increased prevalence of infertility and an accelerated rate… read more here.
Keywords: dna repair; dna; repair genes; analysis ... See more keywords
Repurposing a DNA‐Repair Enzyme for Targeted Protein Degradation
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DOI: 10.1002/cbic.202200053
Abstract: Herein we present the exploration of the utility of DNA demethylase enzymes for targeted protein degradation. Novel benzylguanine substrates are characterized for their ability to control protein degradation in cells. Our data demonstrate the utility… read more here.
Keywords: dna repair; repurposing dna; targeted protein; protein degradation ... See more keywords
Replication Protein A Enhances Kinetics of Uracil DNA Glycosylase on ssDNA and Across DNA Junctions: Explored with a DNA Repair Complex Produced with SpyCatcher/SpyTag Ligation
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200765
Abstract: DNA repair proteins participate in extensive protein−protein interactions that promote the formation of DNA repair complexes. To understand how complex formation affects protein function during base excision repair, we used SpyCatcher/SpyTag ligation to produce a… read more here.
Keywords: dna repair; dna; ssdna; repair ... See more keywords
Clarifying the role of EMSY in DNA repair in ovarian cancer
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DOI: 10.1002/cncr.32135
Abstract: One of the key characteristics of high-grade epithelial ovarian cancer (OC) is that up to 50% of such cases can have defects in the homologous recombination (HR) DNA repair pathway. This in turn should make… read more here.
Keywords: ovarian cancer; role; dna repair; dna ... See more keywords
Germline and somatic DNA repair gene alterations in prostate cancer
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DOI: 10.1002/cncr.32908
Abstract: Emerging evidence has suggested that DNA repair gene alterations may be important in prostate cancer pathogenesis. In the current study, the authors sought to characterize alterations in DNA repair pathway genes in both primary and… read more here.
Keywords: dna repair; gene alterations; prostate cancer; repair gene ... See more keywords