LIM protein Ajuba promotes liver cell proliferation through its involvement in DNA replication and DNA damage control
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14371
Abstract: The LIM‐domain protein Ajuba is associated with cell proliferation, a fundamental process of tissue regeneration and cancer. We report that in the liver, Ajuba expression is increased during regeneration and in tumour cells and tissues.… read more here.
Keywords: dna; cell proliferation; damage; ajuba ... See more keywords
Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13638
Abstract: Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon DNA replication stress is the checkpoint kinase ataxia‐telangiectasia‐and‐RAD3‐related (ATR).… read more here.
Keywords: replication stress; dna replication; atr; leukemic cells ... See more keywords
The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202500838
Abstract: GGH (Gamma‐glutamyl hydrolase) is a folate metabolism enzyme that hydrolyzes intracellular polyglutamylated folates and is highly expressed in various cancers. It remains unclear whether GGH functions as an oncogene and its underlying mechanisms in tumor… read more here.
Keywords: cancer; dna replication; cycle dna; lung cancer ... See more keywords
Homeostasis of DNA Hemi‐Methylation in Arabidopsis through Methylation Maintenance, DNA Replication, and Nucleosome Positioning Mechanisms
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DOI: 10.1002/advs.202505808
Abstract: The DNA methylome in eukaryotes is an equilibrium contributed by maintenance methylation, de novo methylation, demethylation, and DNA replication processes. The asymmetric hemi‐methylation status is thought of as a transient intermediate state en route to… read more here.
Keywords: methylation; dna replication; dna; hemi methylation ... See more keywords
DNA replication timing: Biochemical mechanisms and biological significance
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200097
Abstract: The regulation of DNA replication is a fascinating biological problem both from a mechanistic angle—How is replication timing regulated?—and from an evolutionary one—Why is replication timing regulated? Recent work has provided significant insight into the… read more here.
Keywords: replication; replication timing; timing biochemical; timing regulated ... See more keywords
Keeping the strands together: Rad53 regulation of fork symmetry promotes replication stability
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200141
Abstract: DNAreplicationduringthesynthesis(S-)phaseofthecellcycleisakey step in cell proliferation. DNA replication fidelity and cell cycle checkpoints ensure that transient DNA damage is not converted into stable mutations.Thesedirectlinkstocellproliferationandmutationalavoid-ancemakeDNAreplicationcheckpointsimportanttogenomestability. He and Zhang’s Hypothesis explores how DNA replication complexes are maintained during… read more here.
Keywords: strands together; dna; replication; fork ... See more keywords
Pioneer factors for DNA replication initiation in metazoans
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DOI: 10.1002/bies.202400002
Abstract: Precise DNA replication is fundamental for genetic inheritance. In eukaryotes, replication initiates at multiple origins that are first “licensed” and subsequently “fired” to activate DNA synthesis. Despite the success in identifying origins with specific DNA… read more here.
Keywords: replication; dna replication; pioneer factors; factors dna ... See more keywords
A rAAV2‐producing yeast screening model to identify host proteins enhancing rAAV DNA replication and vector yield
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2725
Abstract: Recombinant adeno‐associated viral vectors (rAAV) are promising therapies for genetic diseases. Although current platforms for recombinant vector production can generate drug material for pre‐clinical and clinical studies, rAAV biomanufacturing will eventually face commercial supply challenges… read more here.
Keywords: vector; dna replication; raav; yield ... See more keywords
Labeling DNA Replication Foci to Visualize Chromosome Territories In Vivo
Sign Up to like & getrecommendations! Published in 2017 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.19
Abstract: While a detailed understanding of chromatin dynamics is needed to explain how higher‐order chromatin organization influences nuclear function, the molecular principles that regulate chromatin mobility in mammalian nuclei remain largely unknown. Here we describe experimental… read more here.
Keywords: labeling dna; dna replication; foci visualize; visualize chromosome ... See more keywords
Evolutionary Transitions of DNA Replication Origins Between Archaea and Bacteria
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.202400527
Abstract: DNA replication origins play a crucial role in cellular division and are evolutionarily conserved across domains. This study investigated the evolutionary transitions of replication origins between archaea and bacteria by analyzing 2733 bacterial and 257… read more here.
Keywords: replication; dna replication; replication origins; archaea bacteria ... See more keywords
Strand-Specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7306-4_17
Abstract: DNA replication initiates at DNA replication origins after unwinding of double-strand DNA(dsDNA) by replicative helicase to generate single-stranded DNA (ssDNA) templates for the continuous synthesis of leading-strand and the discontinuous synthesis of lagging-strand. Therefore, methods… read more here.
Keywords: strand specific; dna; dna replication; strand ... See more keywords