LIM protein Ajuba promotes liver cell proliferation through its involvement in DNA replication and DNA damage control
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14371
Abstract: The LIM‐domain protein Ajuba is associated with cell proliferation, a fundamental process of tissue regeneration and cancer. We report that in the liver, Ajuba expression is increased during regeneration and in tumour cells and tissues.… read more here.
Keywords: dna; cell proliferation; damage; ajuba ... See more keywords
DNA replication timing: Biochemical mechanisms and biological significance
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200097
Abstract: The regulation of DNA replication is a fascinating biological problem both from a mechanistic angle—How is replication timing regulated?—and from an evolutionary one—Why is replication timing regulated? Recent work has provided significant insight into the… read more here.
Keywords: replication; replication timing; timing biochemical; timing regulated ... See more keywords
Keeping the strands together: Rad53 regulation of fork symmetry promotes replication stability
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200141
Abstract: DNAreplicationduringthesynthesis(S-)phaseofthecellcycleisakey step in cell proliferation. DNA replication fidelity and cell cycle checkpoints ensure that transient DNA damage is not converted into stable mutations.Thesedirectlinkstocellproliferationandmutationalavoid-ancemakeDNAreplicationcheckpointsimportanttogenomestability. He and Zhang’s Hypothesis explores how DNA replication complexes are maintained during… read more here.
Keywords: strands together; dna; replication; fork ... See more keywords
A rAAV2‐producing yeast screening model to identify host proteins enhancing rAAV DNA replication and vector yield
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2725
Abstract: Recombinant adeno‐associated viral vectors (rAAV) are promising therapies for genetic diseases. Although current platforms for recombinant vector production can generate drug material for pre‐clinical and clinical studies, rAAV biomanufacturing will eventually face commercial supply challenges… read more here.
Keywords: vector; dna replication; raav; yield ... See more keywords
Labeling DNA Replication Foci to Visualize Chromosome Territories In Vivo
Sign Up to like & getrecommendations! Published in 2017 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.19
Abstract: While a detailed understanding of chromatin dynamics is needed to explain how higher‐order chromatin organization influences nuclear function, the molecular principles that regulate chromatin mobility in mammalian nuclei remain largely unknown. Here we describe experimental… read more here.
Keywords: labeling dna; dna replication; foci visualize; visualize chromosome ... See more keywords
Strand-Specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7306-4_17
Abstract: DNA replication initiates at DNA replication origins after unwinding of double-strand DNA(dsDNA) by replicative helicase to generate single-stranded DNA (ssDNA) templates for the continuous synthesis of leading-strand and the discontinuous synthesis of lagging-strand. Therefore, methods… read more here.
Keywords: strand specific; dna; dna replication; strand ... See more keywords
Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-6955-0_19
Abstract: Proper regulation of DNA replication ensures the faithful transmission of genetic material essential for optimal cellular and organismal physiology. Central to this regulation is the activity of a set of enzymes that induce or reverse… read more here.
Keywords: dna replication; proteasome system; replication; regulation ... See more keywords
Initiation of DNA Replication in the Archaea.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-6955-0_5
Abstract: Organisms within the archaeal domain of life possess a simplified version of the eukaryotic DNA replication machinery. While some archaea possess a bacterial-like mode of DNA replication with single origins of replication per chromosome, the… read more here.
Keywords: initiation dna; dna replication; replication; replication archaea ... See more keywords
Linking the organization of DNA replication with genome maintenance
Sign Up to like & getrecommendations! Published in 2018 at "Current Genetics"
DOI: 10.1007/s00294-018-0923-8
Abstract: The spatial and temporal organization of genome duplication, also referred to as the replication program, is defined by the distribution and the activities of the sites of replication initiation across the genome. Alterations to the… read more here.
Keywords: genome maintenance; dna replication; replication; organization ... See more keywords
Mgs1 function at G-quadruplex structures during DNA replication
Sign Up to like & getrecommendations! Published in 2020 at "Current Genetics"
DOI: 10.1007/s00294-020-01128-1
Abstract: The coordinated action of DNA polymerases and DNA helicases is essential at genomic sites that are hard to replicate. Among these are sites that harbour G-quadruplex DNA structures (G4). G4s are stable alternative DNA structures,… read more here.
Keywords: function quadruplex; dna replication; dna structures; replication ... See more keywords
Checkpoint functions of RecQ helicases at perturbed DNA replication fork.
Sign Up to like & getrecommendations! Published in 2021 at "Current genetics"
DOI: 10.1007/s00294-020-01147-y
Abstract: DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains… read more here.
Keywords: dna replication; recq helicases; functions recq; replication checkpoint ... See more keywords