Electrochemical DNA Scaffold-Based Sensing Platform for Multiple Modes of Protein Assay and a Keypad Lock System.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00800
Abstract: Development of a flexible, easy-to-use, and well-controllable DNA-based sensing platform would provide enormous opportunities to boost molecular diagnosis and signal transduction or information processing. Herein, a duplex DNA scaffold containing a bulge was deployed for… read more here.
Keywords: sensing platform; dna scaffold; platform; based sensing ... See more keywords
Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars
Sign Up to like & getrecommendations! Published in 2020 at "ACS Central Science"
DOI: 10.1021/acscentsci.9b01277
Abstract: The constitution, configuration, and flexibility of the core sugars of DNA molecules alter their function in diverse roles. Conformational itineraries of the ribofuranosides (fs) have long been known to finely determine rates of processing, yet… read more here.
Keywords: conformers putative; dna; observation unbiased; dna scaffold ... See more keywords
A modular DNA scaffold to study protein–protein interactions at single-molecule resolution
Sign Up to like & getrecommendations! Published in 2019 at "Nature Nanotechnology"
DOI: 10.1038/s41565-019-0542-7
Abstract: The residence time of a drug on its target has been suggested as a more pertinent metric of therapeutic efficacy than the traditionally used affinity constant. Here, we introduce junctured-DNA tweezers as a generic platform… read more here.
Keywords: single molecule; protein interactions; dna; dna scaffold ... See more keywords
Mechanistic Aspects for the Modulation of Enzyme Reactions on the DNA Scaffold
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196309
Abstract: Cells have developed intelligent systems to implement the complex and efficient enzyme cascade reactions via the strategies of organelles, bacterial microcompartments and enzyme complexes. The scaffolds such as the membrane or protein in the cell… read more here.
Keywords: dna scaffold; mechanistic aspects; aspects modulation; enzyme ... See more keywords