A Facile and Sensitive DNA Sensing of Harmful Algal Blooms Based on Graphene Oxide Nanosheets
Sign Up to like & getrecommendations! Published in 2020 at "Marine Biotechnology"
DOI: 10.1007/s10126-020-09971-6
Abstract: Gene detection has important applications in biology, biomedical engineering, clinical, environmental, and marine fields. Rapid, sensitive, and selective recognition of specific genes is essential in practical applications. In this study, we describe a facile and… read more here.
Keywords: sensitive dna; graphene oxide; oxide nanosheets; dna ... See more keywords
PNA-functionalized magnetic microbeads as substrates for enzyme-labelled voltammetric genoassay for DNA sensing applied to identification of GMO in food.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338297
Abstract: A novel enzyme-labelled voltammetric magnetogenoassay for DNA sensing based on the use of carboxyl-surface coated magnetic microbeads functionalized with PNA probes and subsequent read-out on screen-printed electrode (SPE) substrates was developed. The assay was validated… read more here.
Keywords: dna; pna; labelled voltammetric; magnetic microbeads ... See more keywords
Examining Dynamic Emergent Properties of the DNA Sensing Pathway
Sign Up to like & getrecommendations! Published in 2018 at "IFAC-PapersOnLine"
DOI: 10.1016/j.ifacol.2018.09.017
Abstract: Abstract The DNA sensing pathway is a component of the innate immune system that recognizes DNA in the cytosol of cells. Its main purpose after DNA detection is to promote interferon production, which acts as… read more here.
Keywords: examining dynamic; dna sensing; sensing pathway; dynamic emergent ... See more keywords
High Spatial Resolution of Ultrathin Covalent Organic Framework Nanopores for Single-Molecule DNA Sensing.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01708
Abstract: Ultrathin nanosheets of two-dimensional covalent organic frameworks covered a quartz nanopipette and then acted as a nanopore device for single-molecule DNA sensing. Our results showed that a single DNA homopolymer as short as 6 bases… read more here.
Keywords: single molecule; dna; dna sensing; covalent organic ... See more keywords
Erratum: DNA sensing in senescence
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/ncb3644
Abstract: This corrects the article DOI: 10.1038/ncb3603 read more here.
Keywords: erratum dna; sensing senescence; dna sensing; biology ... See more keywords
TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-02936-3
Abstract: Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) produces the second messenger cGAMP, which… read more here.
Keywords: cgas; production; dna; cytosolic dna ... See more keywords
Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53515-8
Abstract: Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated. We found that the sensitivity of ATRTs to EZH2 inhibition… read more here.
Keywords: atypical teratoid; teratoid rhabdoid; dna sensing; mimicry ... See more keywords
Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59186-3
Abstract: The interplay between tumor cells and the microenvironment significantly influences cancer progression. Here, we report a significant role of the transcription factor FOXM1 in shaping the tumor immune landscape. Single-cell sequencing reveals that tumor-intrinsic FOXM1… read more here.
Keywords: cancer; sensing pathway; dna sensing; tumor ... See more keywords
Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abb4565
Abstract: DNA sensing inhibition by viral cGAMP nuclease impairs anti-viral responses and protective immunity. Cells contain numerous immune sensors to detect virus infection. The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and activates innate immune… read more here.
Keywords: infection; cgamp nuclease; dna sensing; dna ... See more keywords
cGAS in action: Expanding roles in immunity and inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aat8657
Abstract: cGAS sensing of DNA: A comprehensive look The immune system uses the cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) signaling pathway to detect the presence of intracellular DNA. This is beneficial because cytosolic DNA is… read more here.
Keywords: innate; cgas; dna; self dna ... See more keywords
Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 Activation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01934-18
Abstract: Despite widespread vaccination, Marek’s disease (MD) continues to pose major challenges for the poultry industry worldwide. MDV causes immunosuppression and deadly lymphomas in chickens, suggesting that this virus has developed a successful immune evasion strategy.… read more here.
Keywords: vp23; response; dna; activation ... See more keywords