Cytosolic DNA sensor activation inhibits HIV infection of macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28253
Abstract: Cytosolic recognition of microbial DNA in macrophages results in the activation of the interferon (IFN)‐dependent antiviral innate immunity. Here, we examined whether activating DNA sensors in peripheral blood monocyte‐derived macrophages (MDMs) can inhibit human immunodeficiency… read more here.
Keywords: dna; dna sensors; hiv infection; dna sensor ... See more keywords
Highly sensitive detection of Hg2+ using molybdenum disulfide-DNA sensors
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Physics"
DOI: 10.1016/j.chemphys.2020.110758
Abstract: Abstract Mercury ion (Hg2+) is one of the heavy metal ions that cause significant physiological damage to an organism even in trace amount. To facilitate Hg2+ detection, a thiol-modified DNA was used as helper sequence… read more here.
Keywords: dna sensors; detection; hg2; dna ... See more keywords
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1717190115
Abstract: Significance Necroptosis is a regulated form of necrotic cell death that is important in physiology and human diseases. However, the signaling process leading to eventual cell death in necroptosis remains unclear. We show that PUMA,… read more here.
Keywords: dna sensors; death; dna; puma ... See more keywords
Cytosolic DNA Sensors and CNS Responses to Viral Pathogens
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.576263
Abstract: Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antiviral… read more here.
Keywords: dna sensors; dna; infection; responses viral ... See more keywords
Cytosolic DNA sensors and glial responses to endogenous DNA
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1130172
Abstract: Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic… read more here.
Keywords: endogenous dna; dna; sensors glial; dna sensors ... See more keywords
Who and how, DNA sensors in NETs-driven inflammation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1190177
Abstract: During infections, neutrophil extracellular traps act like a meshwork of molecules that captures microbes. In contrast, during sterile inflammation the presence of NETs is usually associated with tissue damage and uncontrolled inflammation. In this context,… read more here.
Keywords: inflammation; sensors nets; dna sensors; driven inflammation ... See more keywords
DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.00226
Abstract: Objectives The host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by… read more here.
Keywords: dna sensors; infection; hhv hhv; hhv ... See more keywords
Interrogating Host Antiviral Environments Driven by Nuclear DNA Sensing: A Multiomic Perspective
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10121591
Abstract: Nuclear DNA sensors are critical components of the mammalian innate immune system, recognizing the presence of pathogens and initiating immune signaling. These proteins act in the nuclei of infected cells by binding to foreign DNA,… read more here.
Keywords: dna sensors; dna; host antiviral; nuclear dna ... See more keywords
Immune Regulation by Cytosolic DNA Sensors in the Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15072114
Abstract: Simple Summary Cytosolic DNA sensors (CDSs), expressed in various types of immune and tumor cells, recognize double-stranded DNA (dsDNA) in the cytoplasm. These molecules are activated after the dsDNA recognition and initiate a cascade of… read more here.
Keywords: dna; anti tumor; dna sensors; tumor microenvironment ... See more keywords
The Interplay between Viruses and Host DNA Sensors
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040666
Abstract: DNA virus infections are often lifelong and can cause serious diseases in their hosts. Their recognition by the sensors of the innate immune system represents the front line of host defence. Understanding the molecular mechanisms… read more here.
Keywords: dna; interplay viruses; dna sensors; viruses host ... See more keywords
DNA sensors, crucial receptors to resist pathogens, are deregulated in colorectal cancer and associated with initiation and progression of the disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer"
DOI: 10.7150/jca.34188
Abstract: Background: DNA sensors are innate immune receptors that detect intracellular endogenous or exogenous DNA. They are critical to trigger immune response against DNA viral and intracellular bacterial infection, and are involved in inflammatory diseases and… read more here.
Keywords: dna sensors; dna; colorectal cancer; expression ... See more keywords