Mgs1 function at G-quadruplex structures during DNA replication
Sign Up to like & getrecommendations! Published in 2020 at "Current Genetics"
DOI: 10.1007/s00294-020-01128-1
Abstract: The coordinated action of DNA polymerases and DNA helicases is essential at genomic sites that are hard to replicate. Among these are sites that harbour G-quadruplex DNA structures (G4). G4s are stable alternative DNA structures,… read more here.
Keywords: function quadruplex; dna replication; dna structures; replication ... See more keywords
Non-canonical DNA structures: Comparative quantum mechanical study.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2018.02.003
Abstract: A study of relative thermodynamic stability of non-canonical DNA structures (triplexes, G-quadruplexes, i-motifs) for the first time was conducted on the basis of quantum chemical DFT/B3LYP/6-31++G (d) calculations. Results of the calculations completely reproduce the… read more here.
Keywords: dna; structures comparative; canonical dna; study ... See more keywords
Uptake and Fate of Fluorescently Labeled DNA Nanostructures in Cellular Environments: A Cautionary Tale
Sign Up to like & getrecommendations! Published in 2019 at "ACS Central Science"
DOI: 10.1021/acscentsci.9b00174
Abstract: Fluorescent dye labeling of DNA oligonucleotides and nanostructures is one of the most used techniques to track their fate and cellular localization inside cells. Here, we report that intracellular fluorescence, and even FRET signals, cannot… read more here.
Keywords: dna; labeled dna; dna structures; fate ... See more keywords
Enhancement of fluorescent resonant energy transfer and the antenna effect in DNA structures with multiple fluorescent dyes
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra01470h
Abstract: This study examines the use of surfactants and metal cations for the enhancement of long range fluorescent resonant energy transfer (FRET) and the antenna effect in double-stranded (ds) DNA structures formed by hybridization of 21mer… read more here.
Keywords: dna; dimerization; dna structures; fluorescent resonant ... See more keywords
A complementary chemical probe approach towards customized studies of G-quadruplex DNA structures in live cells
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05816a
Abstract: G-quadruplex (G4) DNA structures are implicated in central biological processes and are considered promising therapeutic targets because of their links to human diseases such as cancer. However, functional details of how, when, and why G4… read more here.
Keywords: dna structures; quadruplex dna; complementary chemical; phen dc3 ... See more keywords
Structures and stability of simple DNA repeats from bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Journal"
DOI: 10.1042/bcj20190703
Abstract: DNA is a fundamentally important molecule for all cellular organisms due to its biological role as the store of hereditary, genetic information. On the one hand, genomic DNA is very stable, both in chemical and… read more here.
Keywords: repeats bacteria; dna; structures stability; dna structures ... See more keywords
Dynamics of physiologically relevant noncanonical DNA structures: an overview from experimental and theoretical studies.
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/ely026
Abstract: DNA is a complex molecule with phenomenal inherent plasticity and the ability to form different hydrogen bonding patterns of varying stabilities. These properties enable DNA to attain a variety of structural and conformational polymorphic forms.… read more here.
Keywords: dna; dynamics physiologically; noncanonical dna; dna structures ... See more keywords
Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa820
Abstract: Abstract G-quadruplex (G4) structures are stable non-canonical DNA structures that are implicated in the regulation of many cellular pathways. We show here that the G4-stabilizing compound PhenDC3 causes growth defects in Schizosaccharomyces pombe cells, especially… read more here.
Keywords: dna; schizosaccharomyces pombe; strand dna; dna structures ... See more keywords
Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1205
Abstract: Abstract G-quadruplex (G4) DNA structures are linked to key biological processes and human diseases. Small molecules that target specific G4 DNA structures and signal their presence would therefore be of great value as chemical research… read more here.
Keywords: subtle structural; dna; fluorescence light; quadruplex dna ... See more keywords
I-Motif DNA Structures May Regulate Promoters and Telomeres.
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DOI: 10.1158/2159-8290.cd-rw2018-077
Abstract: I-motif DNA structures form in the nuclei of human cells in a cell-cycle and pH dependent manner. read more here.
Keywords: may regulate; dna structures; regulate promoters; structures may ... See more keywords
Non-canonical DNA structures: Diversity and disease association
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.959258
Abstract: A complete understanding of DNA double-helical structure discovered by James Watson and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven decades, this has been a leading light in… read more here.
Keywords: structures diversity; dna; dna structures; canonical dna ... See more keywords