Localized modulation of DNA supercoiling, triggered by the Shigella anti-silencer VirB, is sufficient to relieve H-NS-mediated silencing
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad088
Abstract: Abstract In Bacteria, nucleoid structuring proteins govern nucleoid dynamics and regulate transcription. In Shigella spp., at ≤30°C, the histone-like nucleoid structuring protein (H-NS) transcriptionally silences many genes on the large virulence plasmid. Upon a switch… read more here.
Keywords: dna; virb; dna supercoiling; transcription ... See more keywords
DNA supercoiling-induced shapes alter minicircle hydrodynamic properties
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad183
Abstract: Abstract DNA in cells is organized in negatively supercoiled loops. The resulting torsional and bending strain allows DNA to adopt a surprisingly wide variety of 3-D shapes. This interplay between negative supercoiling, looping, and shape… read more here.
Keywords: supercoiling induced; dna; dna supercoiling; hydrodynamic properties ... See more keywords
Bacterial genome architecture shapes global transcriptional regulation by DNA supercoiling
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz300
Abstract: Abstract DNA supercoiling acts as a global transcriptional regulator in bacteria, that plays an important role in adapting their expression programme to environmental changes, but for which no quantitative or even qualitative regulatory model is… read more here.
Keywords: transcription; global transcriptional; dna; dna supercoiling ... See more keywords
DNA Supercoiling Drives a Transition between Collective Modes of Gene Synthesis
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DOI: 10.1103/physrevlett.127.218101
Abstract: Transcription of genes can be affected by both biochemical and mechanical factors. Recent experiments suggested that the mechanical stress associated with transcription-induced DNA supercoiling is responsible for the transition from cooperative to antagonistic group dynamics… read more here.
Keywords: dna; transcription; gene; dna supercoiling ... See more keywords
Relaxation of DNA supercoiling leads to increased invasion of epithelial cells and protein secretion by Campylobacter jejuni
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13614
Abstract: Invasion of intestinal epithelial cells by Campylobacter jejuni is a critical step during infection of the intestine by this important human pathogen. In this study we investigated the role played by DNA supercoiling in the… read more here.
Keywords: dna supercoiling; epithelial cells; relaxation dna; invasion ... See more keywords