Human 8‐Oxoguanine Glycosylase OGG1 Cleaves Abasic Sites and Covalently Conjugates to 3′‐DNA Termini via Cysteine and Histidine Addition
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400705
Abstract: 8‐Oxoguanine glycosylase 1 (OGG1) repairs the major oxidative DNA damage, 8‐oxo‐2′‐deoxyguanosine. It has been reported that OGG1 incises the most frequently formed DNA lesion, apurinic/apyrimidinic (AP) site, and in the process a stable DNA‐OGG1 cross‐link… read more here.
Keywords: dna termini; cysteine histidine; histidine addition; glycosylase ogg1 ... See more keywords
Targeting DNA termini with a small-molecule natural product analogue: a DNA end-binder (DEB) to augment DNA double-strand breaks
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf1027
Abstract: Abstract DNA double-strand breaks generate exposed DNA ends, which, if left unrepaired, can be highly deleterious. Eukaryotic cells have evolved multiple mechanisms to safeguard these DNA ends and maintain genomic integrity. This study screened synthetic… read more here.
Keywords: dna termini; dna end; small molecule; dna ... See more keywords