Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13904
Abstract: DNA topoisomerase II beta (TOP2B) has a role in transcriptional regulation. Here, to further investigate transcriptional regulation by TOP2B, we used RNA‐sequencing and real‐time PCR to analyse the differential gene expression profiles of wild‐type and… read more here.
Keywords: dna topoisomerase; topoisomerase beta; carbonyl reductase;
Cytotoxic alkaloids from Pogonopus tubulosus: G2/M cell cycle arrest and inhibition of DNA topoisomerase IIα by isotubulosine
Sign Up to like & getrecommendations! Published in 2018 at "Phytotherapy Research"
DOI: 10.1002/ptr.6059
Abstract: Phytochemical investigation of Pogonopus tubulosus trunk led to the isolation of isotubulosine and alangiside, tetrahydroisoquinoline indolic monoterpene alkaloids reported here for the first time for the family Rubiaceae and the genus Pogonopus, respectively. Isotubulosine proved… read more here.
Keywords: dna topoisomerase; arrest; isotubulosine; pogonopus tubulosus ... See more keywords
Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02472-9
Abstract: The compounds reducing tumor cell viability and disrupting DNA topoisomerase reactions have been widely used in anticancer drug development. Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is a potent intercalating agent that interferes with nucleic acid processing through interaction with… read more here.
Keywords: ellipticine derivatives; dna topoisomerase; topoisomerase; effects human ... See more keywords
Molecular Evolution of DNA Topoisomerase III Beta (TOP3B) in Metazoa.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular evolution"
DOI: 10.1007/s00239-021-10011-7
Abstract: DNA topoisomerase III beta (TOP3B) is unique by operating on both DNA and RNA substrates to regulate gene expression and genomic stability. Mutations in human TOP3B are linked to neurodevelopmental and cognitive disorders, highlighting its… read more here.
Keywords: iii beta; evolution; topoisomerase iii; dna ... See more keywords
Expression and Purification of Vaccinia Virus DNA Topoisomerase IB Produced in the Silkworm–Baculovirus Expression System
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biotechnology"
DOI: 10.1007/s12033-019-00184-4
Abstract: Type IB DNA topoisomerases are enzymes to change the topological state of DNA molecules and are essential in studying replication, transcription, and recombination of nucleic acids in vitro. DNA topoisomerase IB from Vaccinia virus (vTopIB)… read more here.
Keywords: system; dna; dna topoisomerase; rvtopib ... See more keywords
DNA topoisomerase I and DNA gyrase as targets for TB therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.11.006
Abstract: Tuberculosis (TB) is the deadliest bacterial disease in the world. New therapeutic agents are urgently needed to replace existing drugs for which resistance is a significant problem. DNA topoisomerases are well-validated targets for antimicrobial and… read more here.
Keywords: dna topoisomerase; topoisomerase dna; dna gyrase; dna ... See more keywords
Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.04.040
Abstract: Our previous studies reveal that indolizinoquinolinedione scaffold is a base to develop novel DNA topoisomerase IB (TOP1) catalytic inhibitors. In this work, twenty-three novel indolizinoquinolinedione derivatives were synthesized. TOP1-mediated relaxation, nicking and unwinding assays revealed… read more here.
Keywords: dna topoisomerase; indolizinoquinolinedione; indolizinoquinolinedione derivatives; catalytic inhibitors ... See more keywords
Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0965-5
Abstract: Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are unresectable at diagnosis and minimally responsive to conventional treatment, lending urgency… read more here.
Keywords: drugs mtor; topoisomerase targeted; dna topoisomerase; nerve sheath ... See more keywords
Ansavaricins F–I, new DNA topoisomerase inhibitors produced by Streptomyces sp. S012
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra00961e
Abstract: Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. In this study, four new polyketides of ansamycin… read more here.
Keywords: streptomyces s012; topoisomerase inhibitors; dna; dna topoisomerase ... See more keywords
DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2023985
Abstract: ABSTRACT DNA topoisomerase II alpha (TOP2A) reportedly plays a crucial role in several cancers, however, the precise regulatory role of TOP2A in metastatic characteristics of glioma is still poorly understood. Herein, we sought to elucidate… read more here.
Keywords: topoisomerase alpha; top2a; characteristics glioma; dna topoisomerase ... See more keywords
Determination of T Cell Responses in Thai Systemic Sclerosis Patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/5072154
Abstract: Objectives This study is aimed at determining the role of T cells by assessing the numbers of IFN-γ- and IL-2-secreting T cells following stimulation with peptides derived from DNA topoisomerase-I protein in Thai SSc patients.… read more here.
Keywords: dna topoisomerase; topoisomerase protein; stimulation; ssc patients ... See more keywords