DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis
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DOI: 10.1002/bies.202000286
Abstract: DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism. As we review here, current structural approaches have revealed unprecedented insights… read more here.
Keywords: dna topoisomerases; advances understanding; topoisomerases advances; dna ... See more keywords
Type I DNA Topoisomerases.
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DOI: 10.1021/acs.jmedchem.6b00966
Abstract: DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental… read more here.
Keywords: dna topoisomerases; dna; chemistry; type dna ... See more keywords
DNA topoisomerases as additional targets for anticancer monofunctional platinum(II) complexes.
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DOI: 10.1039/d0dt02608e
Abstract: Topoisomerases are ubiquitous enzymes and important targets for DNA-oriented anticancer drugs. Two mitochondrion-targeted monofunctional platinum(ii) complexes, [Pt(ortho-PPh3CH2Py)(NH3)2Cl](NO3)2 (OPT) and [Pt(para-PPh3CH2Py)(NH3)2Cl](NO3)2 (PPT; PPh3 = triphenylphosphonium, Py = pyridine), show significant inhibition towards the activity of DNA… read more here.
Keywords: monofunctional platinum; dna topoisomerases; dna; platinum complexes ... See more keywords