Increased PARP1‐DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1‐DNA trapping is correlated with PARP1 inhibitor's cytotoxicity
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DOI: 10.1002/ijc.32131
Abstract: PARP1 inhibitors (PARPis) are used clinically during cancer therapy and are thought to exert their cytotoxicity through PARP1 polymerase inhibition and PARP1‐DNA trapping. Here, we showed no significant correlation between PARP1‐DNA trapping and cytotoxicity induced… read more here.
Keywords: dna; inhibition; dna trapping; cytotoxicity ... See more keywords
Abstract 6111: Design of a small molecule screening assay to detect DNA trapping of PARP1/2
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DOI: 10.1158/1538-7445.am2023-6111
Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors are currently used in the clinic for the treatment of tumors with a defective DNA damage response (DDR). When PARP1 or PARP2 binds damaged DNA, it adds poly(ADP-ribose) chains to its… read more here.
Keywords: dna; parp1 parp2; dna trapping; parp1 ... See more keywords