Biodegradable Microrobots for DNA Vaccine Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202921
Abstract: The delivery of nucleic acid vaccine to stimulate host immune responses against COVID-19 shows promise. However, nucleic acid vaccines have drawbacks, including rapid clearance and poor cellular uptake, that limit their therapeutic potential. Microrobots can… read more here.
Keywords: biodegradable microrobots; dna vaccine; microrobots dna; vaccine delivery ... See more keywords
Minicircle DNA Vaccine Purification and E7 Antigen Expression Assessment.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0872-2_11
Abstract: Human papillomavirus (HPV ) has been extensively associated with the development of cervical cancer due to the expression of oncoproteins like E7. This protein can interfere with pRB tumor suppressor activity, enabling the uncontrolled proliferation… read more here.
Keywords: minicircle dna; dna; antigen expression; expression ... See more keywords
Recombinant DNA vaccine of Hantavirus Gn and LAMP1 induced long‐term immune protection in mice
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2016.12.001
Abstract: Background Prophylaxis is widely adopted the best choice against Hemorrhagic fever with renal syndrome (HFRS) caused by Hantavirus. However, loss of memory immune response maintenance remains as major shortcoming in current HFRS vaccine. A recombinant… read more here.
Keywords: pvax lamp; vaccine; dna vaccine; long term ... See more keywords
An oral double-targeted DNA vaccine induces systemic and intestinal mucosal immune responses and confers high protection against Vibrio mimicus in grass carps
Sign Up to like & getrecommendations! Published in 2019 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2019.02.006
Abstract: Abstract Vibrio mimicus (V. mimicus) is an enteric pathogen causing serious vibriosis in aquatic animals, and intestinal mucosal immunity elicited by oral DNA vaccines plays a vital role in the resistance to the pathogen. Yet,… read more here.
Keywords: dna vaccine; double targeted; mimicus; targeted dna ... See more keywords
Bacterial ghost as delivery vehicles loaded with DNA vaccine induce significant and specific immune responses in common carp against spring viremia of carp virus
Sign Up to like & getrecommendations! Published in 2019 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2019.02.021
Abstract: Abstract Although vaccine is a prophylaxis measure for the contagious and fatal disease caused by spring viremia of carp virus (SVCV), until now, no commercial vaccine is available for worldwide use. To find more effective… read more here.
Keywords: dna vaccine; carp; viremia carp; spring viremia ... See more keywords
Impacts of oral Vibrio mimicus double-targeted DNA vaccine on the gut microbiota in grass carps (Ctenopharyngodon idella) and correlations with intestinal mucosa innate immunity
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2020.736201
Abstract: Abstract Intestinal microbiota plays an important role in host metabolism, immunity and health maintenance. In previous studies, we developed an oral double-targeted DNA vaccine of Vibrio mimicus and demonstrated that the vaccine could elicit significantly… read more here.
Keywords: immunity; gut; microbiota; vibrio ... See more keywords
A minigene DNA vaccine encoding peptide epitopes derived from Galectin-1 has protective antitumoral effects in a model of neuroblastoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.03.020
Abstract: We recently identified Galectin-1 (Gal-1), a β-galactoside-binding lectin, as a novel immune regulator in neuroblastoma (NB). Here, we characterized the tolerogenic function of Gal-1 within the CD8+ T cell compartment and further evaluated its relevance… read more here.
Keywords: minigene dna; dna; encoding peptide; vaccine encoding ... See more keywords
Biomacromolecules of chitosan - Bacopa saponin based LipL32 gene delivery system for leptospirosis therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental research"
DOI: 10.1016/j.envres.2021.111699
Abstract: Leptospirosis is a severe bacterial infectious disease caused by the organisms belonging to the genus of Leptospira. The chitosan/Bacopa saponin/tripolyphosphate (CS/BS/TPP) nanoparticles conjugated with recombinant DNA vaccines were designed against Leptospirosis. Chitosan, a polysaccharide is… read more here.
Keywords: dna; leptospirosis; chitosan bacopa; vaccine ... See more keywords
Enhanced immune response to a dual-promoter anti-caries DNA vaccine orally delivered by attenuated Salmonella typhimurium.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2017.01.007
Abstract: The strength of immune responses induced by DNA vaccine is closely associated with the expression level of cloned antigens available to the antigen presenting cells (APCs). To acquire a larger and more persistent amount of… read more here.
Keywords: salmonella; attenuated salmonella; promoter; anti caries ... See more keywords
Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of Non-obese Diabetic Mice with Sjögren's Syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.07.005
Abstract: BACKGROUND Overexpression of CD40 has been reported in patients with primary Sjögren's syndrome (pSS). The increased CD40 expression promote autoimmune response and enhance inflammation in pSS. The aim of this study is to block CD40-CD154… read more here.
Keywords: cd40 dna; pathology; dna vaccine; cd40 ... See more keywords
Antigenic potential of a recombinant polyvalent DNA vaccine against pathogenic leptospiral infection.
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DOI: 10.1016/j.micpath.2018.08.028
Abstract: Leptospirosis is a serious epidemic disease caused by pathogenic Leptospira species. The disease is endemic in most tropical and sub-tropical regions of the world. Currently, there is no effective polyvalent vaccine for prevention against most… read more here.
Keywords: dna; infection; polyvalent; pathogenic leptospiral ... See more keywords