Design and Preparation of Solid Lipid Nanoparticle (SLN)-Mediated DNA Vaccines.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1892-9_18
Abstract: Increasing application of nucleic acid vaccines is driving demand for new delivery systems to improve stability and efficacy of DNA vaccines. Solid lipid nanoparticles (SLN) are a particulate carrier system composed of a solid lipid… read more here.
Keywords: dna; design preparation; dna vaccines; solid lipid ... See more keywords
DNA vaccines: prime time is now
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Immunology"
DOI: 10.1016/j.coi.2020.01.006
Abstract: Recently newer synthetic DNA vaccines have been rapidly advanced to clinical study and have demonstrated an impressive degree of immune potency and tolerability. Improvements in DNA delivery over prior needle and syringe approaches include jet… read more here.
Keywords: vaccines prime; dna; delivery; dna vaccines ... See more keywords
DNA vaccines against COVID-19: Perspectives and challenges
Sign Up to like & getrecommendations! Published in 2020 at "Life Sciences"
DOI: 10.1016/j.lfs.2020.118919
Abstract: The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated with several fatal cases worldwide. The rapid spread of this pathogen and… read more here.
Keywords: perspectives challenges; vaccines covid; dna vaccines; coronavirus ... See more keywords
Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.11.072
Abstract: Pfs48/45 and Pfs25 are leading candidates for the development of Plasmodium falciparum transmission blocking vaccines (TBV). Expression of Pfs48/45 in the erythrocytic sexual stages and presentation to the immune system during infection in the human… read more here.
Keywords: pfs48; dna; dna vaccines; pfs25 ... See more keywords
Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44875
Abstract: MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to >25 countries since 2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) in the Arabian Peninsula highlight the ongoing public… read more here.
Keywords: protein; immunogenicity; full length; dna vaccines ... See more keywords
Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2120565
Abstract: Abstract Vaccinations, especially DNA vaccines that promote host immunity, are the most effective interventions for tuberculosis (TB) control. However, the vaccine delivery system exhibits a significant impact on the protective effects of the vaccine. Recently,… read more here.
Keywords: dna vaccines; delivery systems; nanomaterial based; vaccine delivery ... See more keywords
Prototype DNA vaccines for SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.369.6505.783-k
Abstract: Coronavirus The development of a vaccine to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent biomedical need. Yu et al. designed a series of prototype DNA vaccines against the SARS-CoV-2 spike… read more here.
Keywords: prototype dna; sars cov; dna vaccines; vaccines sars ... See more keywords
Efficient Immunization of BALB/c Mice against Pathogenic Brucella melitensis and B. ovis: Comparing Cell-Mediated and Protective Immune Responses Elicited by pCDNA3.1 and pVAX1 DNA Vaccines Coding for Omp31 of Brucella melitensis
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Biotechnology"
DOI: 10.30498/ijb.2021.2618
Abstract: Background: Brucella spp. are intracellular pathogens, therefore cell-mediated immunity is the main response to inhibit survival and growth of the bacteria in vertebrate host. Objective: Many eukaryotic plasmid vectors are being used in setting up… read more here.
Keywords: dna vaccines; omp31; brucella melitensis; brucella ... See more keywords
Immune efficacy of DNA vaccines based on oprL and oprF genes of Pseudomonas aeruginosa in chickens
Sign Up to like & getrecommendations! Published in 2018 at "Poultry Science"
DOI: 10.3382/ps/pey307
Abstract: ABSTRACT Pseudomonas aeruginosa (P. aeruginosa) is a zoonotic pathogen that can infect a variety of animals, including poultry. However, as there is no commercial vaccine available it is imperative that new and effective vaccines are… read more here.
Keywords: dna; dna vaccines; oprf genes; oprl oprf ... See more keywords
Manganese-based nanoadjuvants for enhancement of immune effect of DNA vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1053872
Abstract: As a highly pathogenic avian influenza virus, influenza A (H5N1) has been reported to infect humans, posing a major threat to both poultry industry and public health. It is an urgent need to develop a… read more here.
Keywords: dna; dna vaccines; immune effect; effect dna ... See more keywords
T Cell Responses Induced by DNA Vaccines Based on the DENV2 E and NS1 Proteins in Mice: Importance in Protection and Immunodominant Epitope Identification
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01522
Abstract: The importance of the cellular immune response against DENV has been increasingly highlighted in the past few years, in particular for vaccine development. We have previously constructed two plasmids, pE1D2, and pcTPANS1, encoding the envelope… read more here.
Keywords: protection; importance; response; ns1 proteins ... See more keywords