Neurotensin as a source of cyclic AMP and co-mitogen in fibrolamellar hepatocellular carcinoma
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DOI: 10.18632/oncotarget.27149
Abstract: Fibrolamellar hepatocellular carcinomas (FL-HCCs) possess a unique mutation that encodes a chimeric form of protein kinase A (DNAJ-PKAc), which includes a chaperonin binding domain. DNAJ-PKAc retains most of the biochemical properties of the native enzyme,… read more here.
Keywords: neurotensin source; camp; fibrolamellar hepatocellular; source ... See more keywords
An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.44187
Abstract: Fibrolamellar carcinoma (FLC) is a rare liver cancer. FLCs uniquely produce DNAJ-PKAc, a chimeric enzyme consisting of a chaperonin-binding domain fused to the Cα subunit of protein kinase A. Biochemical analyses of clinical samples reveal… read more here.
Keywords: dnaj pkac; scaffolding function; fibrolamellar carcinoma; acquired scaffolding ... See more keywords