DNAJA1 positively regulates amino acid‐stimulated milk protein and fat synthesis in bovine mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3918
Abstract: Several cellular processes, including the recovery of misfolded proteins, the folding of polypeptide chains, transit of polypeptides across the membrane, construction and disassembly of protein complexes, and modulation of protein control, are carried out by… read more here.
Keywords: amino acid; milk protein; protein; dnaja1 ... See more keywords
Abstract 6803: RNF5-DNAJA1 axis dictates selinexor sensitivity of multiple myeloma by regulating mitochondrial function
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6803
Abstract: Selinexor is a First-in-Class XPO1 Inhibitor approved for relapsed or refractory multiple myeloma (RRMM), but the overall response rate remains unsatisfactory. The main mechanism by which Selinexor kill MM cells is to suppress the export… read more here.
Keywords: multiple myeloma; rnf5 dnaja1; dnaja1 axis; regulating mitochondrial ... See more keywords
Leveraging the Structure of DNAJA1 to Discover Novel Potential Pancreatic Cancer Therapies
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101391
Abstract: Pancreatic cancer remains one of the deadliest forms of cancer with a 5-year survival rate of only 11%. Difficult diagnosis and limited treatment options are the major causes of the poor outcome for pancreatic cancer.… read more here.
Keywords: pancreatic cancer; leveraging structure; dnaja1; cancer ... See more keywords
Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174187
Abstract: Simple Summary The tumor suppressor p53 is frequently mutated in human cancer. Accumulation of missense mutant p53 (mutp53) in tumors is crucial for malignant progression, and cancers are often addicted to oncogenic mutp53. However, strategies… read more here.
Keywords: compound; mutant p53; mutp53; domain ... See more keywords