Leveraging the Structure of DNAJA1 to Discover Novel Potential Pancreatic Cancer Therapies
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DOI: 10.3390/biom12101391
Abstract: Pancreatic cancer remains one of the deadliest forms of cancer with a 5-year survival rate of only 11%. Difficult diagnosis and limited treatment options are the major causes of the poor outcome for pancreatic cancer.… read more here.
Keywords: pancreatic cancer; leveraging structure; dnaja1; cancer ... See more keywords
Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin
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DOI: 10.3390/cancers14174187
Abstract: Simple Summary The tumor suppressor p53 is frequently mutated in human cancer. Accumulation of missense mutant p53 (mutp53) in tumors is crucial for malignant progression, and cancers are often addicted to oncogenic mutp53. However, strategies… read more here.
Keywords: compound; mutant p53; mutp53; domain ... See more keywords