The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/7982389
Abstract: In a previous study, we found that the short isoform of DNAJB6 (DNAJB6(S)) had been decreased in the striatum of a mouse model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). DNAJB6, one of the… read more here.
Keywords: short isoform; apoptosis; isoform dnajb6; induced apoptosis ... See more keywords
DNAJB6b is Downregulated in Synucleinopathies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Parkinson's Disease"
DOI: 10.3233/jpd-202512
Abstract: Background: α-synuclein (α-syn) aggregation contributes to the progression of multiple neurodegenerative diseases. We recently found that the isoform b of the co-chaperone DNAJB6 is a strong suppressor of α-syn aggregation in vivo and in vitro.… read more here.
Keywords: syn aggregation; disease; dnajb6b downregulated; dnajb6 ... See more keywords