The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-207421
Abstract: Meningioma 1 (MN1) overexpression (OE) is associated with the progression from myelodysplastic syndrome to acute myeloid leukemia (AML) and correlates with poor survival in AML patients. In murine models, MN1-OE in common myeloid progenitors has… read more here.
Keywords: differentiation; intrinsically disordered; dnajb6b; mn1 ... See more keywords
High-Efficiency Expression and Purification of DNAJB6b Based on the pH-Modulation of Solubility and Denaturant-Modulation of Size
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DOI: 10.3390/molecules27020418
Abstract: The chaperone DNAJB6b delays amyloid formation by suppressing the nucleation of amyloid fibrils and increases the solubility of amyloid-prone proteins. These dual effects on kinetics and equilibrium are related to the unusually high chemical potential… read more here.
Keywords: modulation; solubility; expression purification; dnajb6b ... See more keywords