J-Domain Proteins in Bacteria and their Viruses.
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DOI: 10.1016/j.jmb.2020.04.014
Abstract: Molecular chaperones maintain cellular protein homeostasis by acting at almost every step in protein biogenesis pathways. The DnaK/HSP70 chaperone has been associated with almost every known essential chaperone functions in bacteria. To act as a… read more here.
Keywords: proteins bacteria; dnak; domain proteins; bacteria viruses ... See more keywords
Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes
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DOI: 10.1038/s41467-018-04414-2
Abstract: Many bacterial proteins require specific subcellular localization for function. How Escherichia coli proteins localize at one pole, however, is still not understood. Here, we show that the DnaK (HSP70) chaperone controls unipolar localization of the… read more here.
Keywords: dnak; dnak hsp70; ipac; localization ... See more keywords
Evaluation of Potential DnaK Modulating Proline-Rich Antimicrobial Peptides Identified by Computational Screening
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.875233
Abstract: The day is rapidly approaching where current antibiotic therapies will no longer be effective due to the development of multi-drug resistant bacteria. Antimicrobial peptides (AMPs) are a promising class of therapeutic agents which have the… read more here.
Keywords: dnak; proline rich; antimicrobial peptides; activity ... See more keywords
Intranasal Immunization with DnaK Protein Induces Protective Mucosal Immunity against Tuberculosis in CD4-Depleted Mice
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2018.00031
Abstract: Mycobacterium tuberculosis (Mtb) remains a global health challenge due to the limited efficacy of the Mtb vaccine in current use, Bacillus Calmette–Guérin (BCG). To date, there is no available vaccine for immunocompromised individuals. Thus, there… read more here.
Keywords: immunity; dnak; vaccine; mucosal immunity ... See more keywords
Characterization of the interactome profiling of Mycoplasma fermentans DnaK in cancer cells reveals interference with key cellular pathways
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DOI: 10.3389/fmicb.2022.1022704
Abstract: Chaperone proteins are redundant in nature and, to achieve their function, they bind a large repertoire of client proteins. DnaK is a bacterial chaperone protein that recognizes misfolded and aggregated proteins and drives their folding… read more here.
Keywords: cancer; dnak; interactome profiling; cellular pathways ... See more keywords
Role of Mycoplasma Chaperone DnaK in Cellular Transformation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21041311
Abstract: Studies of the human microbiome have elucidated an array of complex interactions between prokaryotes and their hosts. However, precise bacterial pathogen–cancer relationships remain largely elusive, although several bacteria, particularly those establishing persistent intra-cellular infections, like… read more here.
Keywords: mycoplasma; dnak; cellular transformation; transformation ... See more keywords
Structural Communication between the E. coli Chaperones DnaK and Hsp90
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DOI: 10.3390/ijms22042200
Abstract: The 70 kDa and 90 kDa heat shock proteins Hsp70 and Hsp90 are two abundant and highly conserved ATP-dependent molecular chaperones that participate in the maintenance of cellular homeostasis. In Escherichia coli, Hsp90 (Hsp90Ec) and… read more here.
Keywords: dnak; structural communication; communication coli; coli chaperones ... See more keywords