Investigation of measurable residual disease in acute myeloid leukemia by DNA methylation patterns
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01316-z
Abstract: Assessment of measurable residual disease (MRD) upon treatment of acute myeloid leukemia (AML) remains challenging. It is usually addressed by highly sensitive PCR- or sequencing-based screening of specific mutations, or by multiparametric flow cytometry. However,… read more here.
Keywords: dnam; myeloid leukemia; measurable residual; residual disease ... See more keywords
Correspondence regarding two recent publications in npj:schizophrenia about DNAm and accelerated aging in schizophrenia
Sign Up to like & getrecommendations! Published in 2017 at "NPJ Schizophrenia"
DOI: 10.1038/s41537-017-0041-5
Abstract: We read with interest the recent reports by McKinney et al. and Voisey et al. Using ‘the Horvath clock’ of DNA methylation (DNAm) in prefrontal cortex and superior temporal gyrus, both studies reported no evidence… read more here.
Keywords: schizophrenia; accelerated aging; age; dnam ... See more keywords
Telomerase May Paradoxically Accelerate Aging of the DNA Methylome.
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DOI: 10.1089/rej.2018.2073
Abstract: DNA methylation (DNAm) clocks such as the Horvath DNAm clock provide the most accurate biological determination of biological age relative to chronological age available today. However, there is little correlation between DNAm clocks, telomere-based aging… read more here.
Keywords: paradoxically accelerate; telomerase may; dnam; may paradoxically ... See more keywords
Nasal DNA methylation differentiates corticosteroid treatment response in pediatric asthma: A pilot study
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DOI: 10.1371/journal.pone.0186150
Abstract: Background Treatment response to systemic corticosteroid in asthmatic children is heterogeneous and may be mediated by epigenetic mechanism(s). We aim to identify DNA methylation (DNAm) changes responsive to steroid, and DNAm biomarkers that distinguish treatment… read more here.
Keywords: treatment response; response; cpgs; dnam ... See more keywords
Epigenome-wide association study of maternal hemoglobin A1c in pregnancy and cord blood DNA methylation.
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DOI: 10.2217/epi-2020-0279
Abstract: Background: Gestational hyperglycemia is associated with adverse perinatal outcomes and long-term offspring metabolic programming, likely through dysregulation of DNA methylation (DNAm). Materials & methods: We tested associations between maternal HbA1c and cord blood DNAm among… read more here.
Keywords: dnam; dna methylation; cord blood;
Defective DNAM-1 Dependent Cytotoxicity in Hepatocellular Carcinoma-Infiltrating NK Cells
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DOI: 10.3390/cancers14164060
Abstract: Simple Summary Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and the fourth leading cause of cancer-related deaths worldwide. Although therapeutic options have improved in the last few years, mortality remains… read more here.
Keywords: hepatocellular carcinoma; cell; hcc; tumor ... See more keywords
Placental Epigenome-Wide Association Study Identified Loci Associated with Childhood Adiposity at 3 Years of Age
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21197201
Abstract: The aim of this study was to identify placental DNA methylation (DNAm) variations associated with adiposity at 3 years of age. We quantified placental DNAm using the Infinium MethylationEPIC BeadChips. We assessed associations between DNAm… read more here.
Keywords: age; years age; adiposity; dnam ... See more keywords