DNA methylation age acceleration is associated with age of onset in Chinese spinocerebellar ataxia type 3 patients
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2022.02.002
Abstract: Spinocerebellar ataxia type 3 (SCA3), also known as Machado Joseph disease (MJD), is a common dominantly inherited ataxia, and has heterogeneous clinical features and variable age of onset, ranging from 10 to 78 years. Repeats… read more here.
Keywords: age; dnam age; age onset; acceleration associated ... See more keywords
Accelerated DNA methylation aging and increased resilience in veterans: The biological cost for soldiering on
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2018.04.001
Abstract: Accelerated epigenetic aging, the difference between the DNA methylation-predicted age (DNAm age) and the chronological age, is associated with a myriad of diseases. This study investigates the relationship between epigenetic aging and risk and protective… read more here.
Keywords: age; value; resilience; dnam age ... See more keywords
Association Between Posttraumatic Stress Disorder and Epigenetic Age Acceleration in a Sample of Twins
Sign Up to like & getrecommendations! Published in 2021 at "Psychosomatic Medicine"
DOI: 10.1097/psy.0000000000001028
Abstract: Posttraumatic stress disorder (PTSD) may physiologically induce accelerated aging, which can be objectively measured by DNA methylation age acceleration. We investigated the association of a clinical diagnosis of PTSD and symptom severity of PTSD with… read more here.
Keywords: age acceleration; age; dnam age; association ... See more keywords
Biological clocks and physical functioning in monozygotic female twins
Sign Up to like & getrecommendations! Published in 2018 at "BMC Geriatrics"
DOI: 10.1186/s12877-018-0775-6
Abstract: BackgroundBiomarkers of biological aging – DNA methylation age (DNAm age) and leukocyte telomere length (LTL)– correlate strongly with chronological age across the life course. It is, however, unclear how these measures of cellular wear and… read more here.
Keywords: strength; physical functioning; age; chronological age ... See more keywords
Leisure-time physical activity and DNA methylation age—a twin study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Epigenetics"
DOI: 10.1186/s13148-019-0613-5
Abstract: BackgroundEpigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath’s DNA methylation (DNAm) age. Age acceleration, i.e.,… read more here.
Keywords: age; time physical; leisure time; dnam age ... See more keywords
Genetic and environmental causes of variation in epigenetic aging across the lifespan
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-00950-1
Abstract: Background DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variation. However, these studies… read more here.
Keywords: variation; age; environmental causes; genetic environmental ... See more keywords
Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-0822-y
Abstract: Background Ageing-associated molecular changes have been assumed to trigger malignant transformations and the epigenetic clock, and the DNA methylation age has been shown to be highly correlated with chronological age. However, the associations between the… read more here.
Keywords: cervical squamous; age; prognosis; squamous cell ... See more keywords
miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM2.5 exposure in elderly men.
Sign Up to like & getrecommendations! Published in 2017 at "Epigenomics"
DOI: 10.2217/epi-2017-0094
Abstract: AIM We tested whether genetic variation in miRNA processing genes modified the association of PM2.5 with DNA methylation (DNAm) age. PATIENTS & METHODS We conducted a repeated measures study based on 552 participants from the… read more here.
Keywords: pm2; age; mirna processing; dnam age ... See more keywords