Abstract 3219: Assessing strategies to activate DNAM1 signaling and inhibit the TIGIT/PVRIG axis using mathematical modeling
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DOI: 10.1158/1538-7445.am2025-3219
Abstract: PVR (CD155) and CD112 are ligands from the Nectin/Nectin-like family, frequently expressed on various tumor cells. PVR binds to the inhibitory receptors TIGIT and CD96, triggering a direct inhibitory signal in T and NK cells,… read more here.
Keywords: dnam1; pvrig; pvr; tigit pvrig ... See more keywords