Allosteric Control of Peroxidase-Mimicking DNAzyme Activity with Cationic Copolymers.
Sign Up to like & getrecommendations! Published in 2018 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b00201
Abstract: Control of protein conformation and function, induced by the binding of an effector, plays significant roles in modulating biochemical reaction. Although the DNAzymes catalytic activity is similar to protein-based enzymes, reports of allosterically controlled DNAzymes… read more here.
Keywords: dnazyme activity; mimicking dnazyme; allosteric control; activity ... See more keywords
The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d0cc08316j
Abstract: The DNAzyme activity of G-quadruplex/hemin in mitochondria has not been characterized. Herein, we report an unexpected difference in the DNAzyme activity between in vitro assays and in mitochondria. Molecular dynamic simulations illustrate how the interaction… read more here.
Keywords: proximity quadruplex; dnazyme activity; dnazyme; quadruplex hemin ... See more keywords