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   Articles with "dnd1" as a keyword



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Essential role of mouse Dead end1 in the maintenance of spermatogonia.

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recommendations! Published in 2019 at "Developmental biology"

DOI: 10.1016/j.ydbio.2018.11.003

Abstract: Dead end is a vertebrate-specific RNA-binding protein implicated in germ cell development. We have previously shown that mouse Dead end1 (DND1) is expressed in male embryonic germ cells and directly interacts with NANOS2 to cooperatively… read more here.

Keywords: essential role; spermatogonia; dead end1; dnd1 ... See more keywords
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Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.

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recommendations! Published in 2023 at "Human reproduction"

DOI: 10.1093/humrep/dead031

Abstract: STUDY QUESTION Is the vertebrate protein Dead end (DND1) a causative factor for human infertility and can novel in vivo assays in zebrafish help in evaluating this? SUMMARY ANSWER Combining patient genetic data with functional… read more here.

Keywords: zebrafish embryos; dnd1; dnd1 variants; infertility ... See more keywords
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The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation

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recommendations! Published in 2023 at "PLOS Genetics"

DOI: 10.1371/journal.pgen.1010656

Abstract: DND1 is essential to maintain germ cell identity. Loss of Dnd1 function results in germ cell differentiation to teratomas in some inbred strains of mice or to somatic fates in zebrafish. Using our knock-in mouse… read more here.

Keywords: late gestation; protein dnd1; dnd1 gfp; dnd1 ... See more keywords
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A homozygous missense variant in DND1 causes non-obstructive azoospermia in humans

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.1017302

Abstract: Non-obstructive azoospermia (NOA) is a severe factor of male infertility; it affects approximately 1% of the global male population and accounts for 40% of male infertility cases. However, the majority of NOA cases remain idiopathic.… read more here.

Keywords: obstructive azoospermia; homozygous missense; non obstructive; dnd1 ... See more keywords