DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Oncology"
DOI: 10.1007/s13402-020-00526-4
Abstract: Background Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the leading causes of cancer-related deaths in… read more here.
Keywords: pdac; tumor suppressor; oncogenic roles; pancreatic cancer ... See more keywords
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2022.01.012
Abstract: Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be activated from its quiescent contractile phenotype to a… read more here.
Keywords: vascular smooth; phenotype; dnmt1; ddr1 ... See more keywords
The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic silencing of the wwc1 gene, a Hippo/YAP pathway upstream effector, in breast cancer epithelial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.08.011
Abstract: It is well known that epithelial-mesenchymal transition (EMT) can confer cancer cells with invasive and migratory capabilities associated with distant metastasis. As a key upstream factor in the Hippo pathway, Kibra (wwc1 gene) has been… read more here.
Keywords: cancer; wwc1 gene; dnmt1; breast cancer ... See more keywords
Analysis of transcript levels of a few schizophrenia candidate genes in neurons from a transgenic mouse embryonic stem cell model overexpressing DNA Methyltransferase 1 (DNMT1).
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144934
Abstract: Overexpression of DNA Methyltransferase I (DNMT1) is considered as one of the etiological factors for schizophrenia (SZ). However, information on genes subjected to dysregulation because of DNMT1 overexpression is limited. To test whether a larger… read more here.
Keywords: tet tet; dysregulation; transcript levels; dnmt1 ... See more keywords
Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2019.01.011
Abstract: DNA methyltransferase 1 (DNMT1) is required for embryogenesis but roles in late forming organ systems including the prostate, which emerges from the urethral epithelium, have not been fully examined. We used a targeted genetic approach… read more here.
Keywords: bud; dna; prostatic buds; dnmt1 ... See more keywords
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22665-4
Abstract: DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk.… read more here.
Keywords: methylation; line; h4k20me3; dnmt1 ... See more keywords
NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71336-9
Abstract: Epigenetics alternation of non-genetic variation and genome-wide association study proven allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development. We analyzed promoter DNA methylation array to evaluate the associated with increased… read more here.
Keywords: insulin receptor; insulin; type diabetes; dnmt1 ... See more keywords
Analysis of DNMT1 gene variants in progression of neural tube defects—an in silico to in vitro approach
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20220998
Abstract: Abstract Neural tube defects (NTDs) are significant congenital deformities of the central nervous system among which spina bifida is the most common form that occurs due to defect in the neurulation process of embryogenesis. NTDs… read more here.
Keywords: expression; tube defects; dnmt1; gene ... See more keywords
NOTCH-YAP1/TEAD-DNMT1 axis drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.05.007
Abstract: BACKGROUND AND AIM Intrahepatic cholangiocarcinoma (ICC) is a devastating liver cancer with extremely high intra- and inter-tumoral molecular heterogeneity, partly due to its diverse cellular origins. We investigated clinical relevance and the molecular mechanisms underlying… read more here.
Keywords: yap1 tead; dnmt1; yap1; icc development ... See more keywords
Human pulmonary artery smooth muscle cell dysfunction is regulated by miR-509-5p in hypoxic environment
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2044147
Abstract: ABSTRACT Reportedly, dysfunction of human pulmonary arterial smooth muscle cells (PASMCs) is associated with the pathogenesis of pulmonary arterial hypertension (PAH). Herein, the role of miR-509-5p in hypoxia-induced PASMCs and the underlying mechanism were explored.… read more here.
Keywords: regulated mir; human pulmonary; mir 509; dnmt1 ... See more keywords
The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab649
Abstract: Abstract Gene expression is finely and dynamically controlled through the tightly coordinated and interconnected activity of epigenetic modulators, transcription and splicing factors and post-translational modifiers. We have recently identified the splicing factor SLU7 as essential… read more here.
Keywords: protein; dna methylation; slu7; dnmt1 ... See more keywords