Selective chemical tracking of Dnmt1 catalytic activity in live cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cell"
DOI: 10.1016/j.molcel.2022.02.008
Abstract: Summary Enzymatic methylation of cytosine to 5-methylcytosine in DNA is a fundamental epigenetic mechanism involved in mammalian development and disease. DNA methylation is brought about by collective action of three AdoMet-dependent DNA methyltransferases, whose catalytic… read more here.
Keywords: dna; dnmt1 catalytic; chemical tracking; selective chemical ... See more keywords
DNMT1: catalytic and non-catalytic roles in different biological processes.
Sign Up to like & getrecommendations! Published in 2022 at "Epigenomics"
DOI: 10.2217/epi-2022-0035
Abstract: DNMT1 is the main enzyme that uses the information on DNA methylation patterns in the parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA. It is widely known that DNMT1 is a… read more here.
Keywords: different biological; non catalytic; dnmt1 catalytic; catalytic roles ... See more keywords