The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AML
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25517
Abstract: Acute myeloid leukemia (AML) is a genetically heterogeneous disease with a clinical course predicted by recurrent cytogenetic abnormalities and/or gene mutations. The NPM1 insertion mutations define the largest distinct genetic subset, ∼30% of AML, and… read more here.
Keywords: dnmt3a; overall survival; npm1 dnmt3a; inferior overall ... See more keywords
The impact of DNMT3A variant allele frequency and two different comutations on patients with de novo cytogenetically normal acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5764
Abstract: To refine the biological and prognostic significance of DNMT3A mutations in acute myeloid leukemia (AML), we assessed the impact of DNMT3A variant allele frequency (VAF) and its comutations in this study. Using targeted next‐generation sequencing,… read more here.
Keywords: myeloid leukemia; dnmt3a variant; acute myeloid; impact dnmt3a ... See more keywords
DNMT3a‐triggered downregulation of K2p1.1 gene in primary sensory neurons contributes to paclitaxel‐induced neuropathic pain
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32155
Abstract: Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy‐induced neuropathic pain. K2p1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection… read more here.
Keywords: k2p1; paclitaxel induced; dnmt3a; drg ... See more keywords
Identification of De Novo DNMT3A Mutations That Cause West Syndrome by Using Whole-Exome Sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0483-9
Abstract: Epileptic encephalopathies (EEs) are a group of severe neurodevelopmental disorders with extreme genetic heterogeneity. Recent trio-based whole-exome sequencing (WES) studies have demonstrated that de novo mutations (DNMs) play prominent roles in severe EE. In this… read more here.
Keywords: dnmt3a mutations; exome sequencing; dnmt3a; west syndrome ... See more keywords
CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00931-5
Abstract: Chemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of CIPNP is very limited, at least in part due to the largely unknown mechanisms that underlie CIPNP genesis.… read more here.
Keywords: dnmt3a; paclitaxel induced; drg; neurons creb ... See more keywords
Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.018
Abstract: Myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs) arise from common progenitors. Tumor-derived factors redirect differentiation from immune-promoting DCs to tolerogenic MDSCs, an immunological hallmark of cancer. Indeed, in vitro differentiation of DCs from human primary… read more here.
Keywords: suppressor cells; dnmt3a; derived suppressor; dnmt3a dependent ... See more keywords
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.025
Abstract: SUMMARY Somatic mutations in DNMT3A are recurrent events across a range of blood cancers. Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self-renewal at the expense of differentiation. Moreover, DNMT3A mutations… read more here.
Keywords: hscs; dnmt3a; hematopoietic stem; stem cells ... See more keywords
DNMT3a Conditional Deletion in Neuro-epithelium Restores Maternal Diabetes-suppressed Neural Tube Closure Essential Genes Expression and Blocks Maternal Diabetes-activated ER Stress
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.119
Abstract: Global DNA hypermethylation is induced in embryonic neuroepithelium by maternal diabetes, leading to neural tube defects (NTDs). However the underlying mechanism is not clear. Our previous study has demonstrated that the green tea polyphenal Epigallocatechin… read more here.
Keywords: dnmt3a; conditional deletion; deletion; neural tube ... See more keywords
Active fusions of Cas9 orthologs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.05.306
Abstract: Many recent epigenetic studies utilize the advantages of CRISPR/dCas9 based tools in linking certain epigenetic modification with gene expression regulation. Various multifactorial diseases often contain changed epigenetic signatures at many loci, so tools for simultaneously… read more here.
Keywords: dnmt3a; cas9 orthologs; active fusions; fusions cas9 ... See more keywords
Preferential self-interaction of DNA methyltransferase DNMT3A subunits containing the R882H cancer mutation leads to dominant changes of flanking sequence preferences.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167482
Abstract: Somatic R882H DNMT3A mutations occur frequently in AML, but their pathogenic mechanism is unclear. As R882H mutations usually are heterozygous, wildtype (WT) and R882H subunits co-exist in affected cells. R882 is located in the RD… read more here.
Keywords: containing r882h; flanking sequence; dnmt3a; sequence preferences ... See more keywords
Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.12.008
Abstract: Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant… read more here.
Keywords: dnmt3a mutations; dominating negative; dnmt3a; negative dnmt3a ... See more keywords