Identification of De Novo DNMT3A Mutations That Cause West Syndrome by Using Whole-Exome Sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0483-9
Abstract: Epileptic encephalopathies (EEs) are a group of severe neurodevelopmental disorders with extreme genetic heterogeneity. Recent trio-based whole-exome sequencing (WES) studies have demonstrated that de novo mutations (DNMs) play prominent roles in severe EE. In this… read more here.
Keywords: dnmt3a mutations; exome sequencing; dnmt3a; west syndrome ... See more keywords
Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.12.008
Abstract: Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant… read more here.
Keywords: dnmt3a mutations; dominating negative; dnmt3a; negative dnmt3a ... See more keywords
NPM1 and DNMT3A mutations are associated with distinct blast immunophenotype in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2073050
Abstract: ABSTRACT The immune system is important for elimination of residual leukemic cells during acute myeloid leukemia (AML) therapy. Anti-leukemia immune response can be inhibited by various mechanisms leading to immune evasion and disease relapse. Selected… read more here.
Keywords: myeloid leukemia; leukemia; npm1 dnmt3a; acute myeloid ... See more keywords
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors
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DOI: 10.1158/0008-5472.can-20-3761
Abstract: TET2 and DNMT3A mutations affect distinct DNA repair mechanisms and govern the differential sensitivities of oncogenic tyrosine kinase–positive leukemia cells to PARP inhibitors. Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies… read more here.
Keywords: dna repair; tet2; tet2 dnmt3a; dnmt3a mutations ... See more keywords
Abstract 343: Targeting DNA replication as a therapeutic strategy for acute myeloid leukemia with DNMT3A mutations
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-343
Abstract: Acute Myeloid Leukemia (AML) is an aggressive malignancy of the blood system, wherein somatic mutations in epigenetic modifier and chromatin remodeling genes are common. Recurrent somatic mutations in the DNA methyltransferase 3 alpha (DNMT3A) gene… read more here.
Keywords: dnmt3a mutations; dnmt3a; dna; acute myeloid ... See more keywords
DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T-cells in PTCL-NOS.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021015019
Abstract: Peripheral T-cell lymphomas (PTCLs) are heterogenous T-cell neoplasms often associated with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A (DNMT3A) mutations in common PTCL entities, including angioimmunoblastic T-cell lymphoma and novel molecular subtypes identified… read more here.
Keywords: cell; tbx21; dnmt3a; ptcl nos ... See more keywords