Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.050
Abstract: SUMMARY IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism underlying the contrasting roles of IL-10 in inflammation and colon… read more here.
Keywords: dnmt3b; colon; associated colon; colitis ... See more keywords
Regulatory loop between lncRNA FAS-AS1 and DNMT3b controls FAS expression in hydroquinone-treated TK6 cells and benzene-exposed workers.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.114147
Abstract: Hydroquinone (HQ), one of the main metabolites of benzene, is a well-known human leukemogen. However, the specific mechanism of how benzene or HQ contributes to the development of leukemia is unknown. In a previous study,… read more here.
Keywords: tk6 cells; dnmt3b; expression; fas as1 ... See more keywords
SA101 ARE COMT, MIR137, MTHFR AND DNMT3B POLYMORPHIC ALLELES ASSOCIATED WITH SCHIZOPHRENIA SYMPTOMS SEVERITY IN MEN AND WOMEN?
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.173
Abstract: Background The mechanisms that determine the development of schizophrenia, progress notes or clinical manifestation can be different in males and females. The aim of the study was to analyze the association of some key genes… read more here.
Keywords: symptoms severity; schizophrenia; dnmt3b; men women ... See more keywords
Rbm10 regulates inflammation development via alternative splicing of Dnmt3b
Sign Up to like & getrecommendations! Published in 2017 at "International Immunology"
DOI: 10.1093/intimm/dxx067
Abstract: RNA-binding motif 10 (Rbm10) is an RNA-binding protein that regulates alternative splicing, but its role in inflammation is not well defined. Here, we show that Rbm10 controls appropriate splicing of DNA (cytosine-5)-methyltransferase 3b (Dnmt3b), a… read more here.
Keywords: inflammation development; dnmt3b; alternative splicing; rbm10 ... See more keywords
Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa111
Abstract: Abstract DNA methyltransferases are primary enzymes for cytosine methylation at CpG sites of epigenetic gene regulation in mammals. De novo methyltransferases DNMT3A and DNMT3B create DNA methylation patterns during development, but how they differentially implement… read more here.
Keywords: methylation; dnmt3b; dna; structural insights ... See more keywords
ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx163
Abstract: Abstract Hypomorphic mutations in DNA-methyltransferase DNMT3B cause majority of the rare disorder Immunodeficiency, Centromere instability and Facial anomalies syndrome cases (ICF1). By unspecified mechanisms, mutant-DNMT3B interferes with lymphoid-specific pathways resulting in immune response defects. Interestingly,… read more here.
Keywords: transcription; dnmt3b; dnmt3b dysfunction; alternative splicing ... See more keywords
ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky682
Abstract: Abstract The interplay between transcription factors and epigenetic writers like the DNA methyltransferases (DNMTs), and the role of this interplay in gene expression, is being increasingly appreciated. ZBTB24, a poorly characterized zinc-finger protein, or the… read more here.
Keywords: methylation; dnmt3b; dna; transcriptional regulator ... See more keywords
DNMT3B-Mediated Gene Body Methylation Suppresses Aberrant Transcription.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-043
Abstract: DNMT3B methylates intragenic DNA to prevent spurious transcription from cryptic intragenic sites. read more here.
Keywords: transcription; dnmt3b; gene body; mediated gene ... See more keywords
Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-08653-3
Abstract: Background Gastric cancer (GC) has an unwelcoming prognosis when diagnosed at an advanced stage. The purpose of this study was to examine the expression of myosin heavy chain 11 (MYH11) in GC and mechanisms related.… read more here.
Keywords: dnmt3b; myh11 expression; gastric cancer; expression ... See more keywords
piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure.
Sign Up to like & getrecommendations! Published in 2022 at "Aging"
DOI: 10.18632/aging.203965
Abstract: PURPOSE Previous studies found that piRNAs could participate in disease progression by regulating DNA methylation, but there are few reports on their roles in heart failure (HF). METHODS The level of piRNA-6426 in the venous… read more here.
Keywords: methylation; pirna 6426; heart; pirna ... See more keywords
DNMT3B System Dysregulation Contributes to the Hypomethylated State in Ischaemic Human Hearts
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040866
Abstract: A controversial understanding of the state of the DNA methylation machinery exists in ischaemic cardiomyopathy (ICM). Moreover, its relationship to other epigenetic alterations is incomplete. Therefore, we carried out an in-depth study of the DNA… read more here.
Keywords: dnmt3b system; dnmt3b; methylation; dysregulation ... See more keywords