Assembly and performance of a 6.4 T cryogen‐free dynamic nuclear polarization system
Sign Up to like & getrecommendations! Published in 2017 at "Magnetic Resonance in Chemistry"
DOI: 10.1002/mrc.4624
Abstract: We report on the assembly and performance evaluation of a 180‐GHz/6.4 T dynamic nuclear polarization (DNP) system based on a cryogen‐free superconducting magnet. The DNP system utilizes a variable‐field superconducting magnet that can be ramped… read more here.
Keywords: system; cryogen free; polarization; dnp ... See more keywords
Trehalose as an alternative to glycerol as a glassing agent for in vivo DNP MRI
Sign Up to like & getrecommendations! Published in 2020 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.28405
Abstract: In dynamic nuclear polarization (DNP), the solution needs to form a glass to attain significant levels of polarization in reasonable time periods. Molecules that do not form glasses by themselves are often mixed with glass… read more here.
Keywords: glycerol glassing; vivo dnp; glassing agent; dnp ... See more keywords
Physiologically-based pharmacokinetic model for 2,4-dinitrophenol.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacokinetics and pharmacodynamics"
DOI: 10.1007/s10928-022-09806-y
Abstract: New approaches in drug development are needed to address the growing epidemic of obesity as the prevalence of obesity increases worldwide. 2,4-Dinitrophenol (DNP) is an oxidative phosphorylation uncoupling agent that was widely used in the… read more here.
Keywords: model dinitrophenol; based pharmacokinetic; model; pharmacokinetic model ... See more keywords
Neuroprotective effects of 2,4-dinitrophenol in an acute model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.03.018
Abstract: Neurons depend on mitochondria for homeostasis and survival, and thus, mitochondrial dysfunction has been implicated in neurodegenerative diseases, including Parkinson's disease (PD). Increasing evidence indicates the mitochondrial uncoupler, 2,4-dinitrophenol (DNP), protects neurons against neurodegeneration and… read more here.
Keywords: neuroprotective effects; parkinson; dnp; model ... See more keywords
2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.03.020
Abstract: ABSTRACT Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the first exon of the gene huntingtin. There is no treatment to prevent or delay the disease course of HD… read more here.
Keywords: huntington disease; dnp; disease; stress ... See more keywords
Site-Specific Dinitrophenylation of Single-Chain Antibody Fragments for Redirecting a Universal CAR-T Cell against Cancer Antigens.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167513
Abstract: We have previously developed a universal chimeric antigen receptor (CAR), which recognizes dinitrophenyl (DNP) and can redirect T and NK cells to target cancer and HIV antigens using DNP-conjugated antibodies as adaptor molecules. However, the… read more here.
Keywords: single chain; site specific; universal car; dnp ... See more keywords
A quasi-optical and corrugated waveguide microwave transmission system for simultaneous dynamic nuclear polarization NMR on two separate 14.1 T spectrometers.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2018.01.015
Abstract: Nuclear magnetic resonance (NMR) is an intrinsically insensitive technique, with Boltzmann distributions of nuclear spin states on the order of parts per million in conventional magnetic fields. To overcome this limitation, dynamic nuclear polarization (DNP)… read more here.
Keywords: quasi optical; polarization; dnp; polarization nmr ... See more keywords
High-field NMR with dissolution triplet-DNP.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2019.106623
Abstract: Dissolution dynamic nuclear polarization (DNP) has wide variety of important applications such as real-time monitoring of chemical reactions and metabolic imaging. We construct DNP using photoexcited triplet electron spins (Triplet-DNP) apparatus combined with dissolution apparatus… read more here.
Keywords: dissolution; high field; dnp; triplet dnp ... See more keywords
Heteronuclear cross-relaxation effect modulated by the dynamics of N-functional groups in the solid state under 15N DP-MAS DNP.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2020.106688
Abstract: In a typical magic-angle spinning (MAS) dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) experiment, several mechanisms are simultaneously involved when transferring much larger polarization of electron spins to NMR active nuclei of interest. Recently,… read more here.
Keywords: mas dnp; cross relaxation; dnp;
THz-enhanced dynamic nuclear polarized liquid spectrometer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2021.107044
Abstract: Dynamic nuclear polarization (DNP) technology can be utilized to dramatically enhance NMR signal. In this paper, we report on the development of a self-constructed 5 T DNP spectrometer for liquid samples and the 13C DNP… read more here.
Keywords: thz enhanced; liquid; dnp; spectrometer ... See more keywords
Overhauser DNP FFC study of block copolymer diluted solution.
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic resonance imaging"
DOI: 10.1016/j.mri.2018.09.005
Abstract: Overhauser dynamic nuclear polarization (DNP) is the dominating hyperpolarization technique to increasing the nuclear magnetic resonance signal in liquids and diluted systems. The enhancement obtained depends on the overall mobility of the radical-carrying molecule but… read more here.
Keywords: overhauser dnp; dnp ffc; block copolymer; study ... See more keywords