Glucagon-like peptide-1 receptor agonist attenuates diabetic neuropathic pain via inhibition of NOD-like receptor protein 3 inflammasome in brain microglia.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2022.109806
Abstract: AIMS We aimed to explore the evidence of brain microglia activation in diabetic neuropathic pain (DNP) and the effect and mechanism of glucagon-like peptide-1 receptor agonist (GLP-RA) on DNP via brain microglia. METHODS Brain microglia… read more here.
Keywords: brain microglia; dnp rats; glp 1ra; brain ... See more keywords
The implication of transient receptor potential canonical 6 in BDNF-induced mechanical allodynia in rat model of diabetic neuropathic pain.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119308
Abstract: AIMS Brain-derived neurotrophic factor (BDNF) is vital in the pathogenesis of mechanical allodynia with a paucity of reports available regarding diabetic neuropathy pain (DNP). Herein we identified the involvement of BDNF in driving mechanical allodynia… read more here.
Keywords: dnp rats; allodynia; mechanical allodynia; bdnf induced ... See more keywords