Double-negative T cells with a distinct transcriptomic profile are abundant in the peripheral blood of patients with breast cancer
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DOI: 10.1007/s10549-024-07477-6
Abstract: Double-negative T (DNT) cells comprise a distinct subset of T lymphocytes that have been implicated in immune responses. The aim of this study was to characterize the peripheral DNT population in breast cancer (BC) patients.… read more here.
Keywords: peripheral blood; breast cancer; double negative; dnt cells ... See more keywords
Nonspecific increase of αβTCR+ double-negative T cells in pediatric rheumatic diseases
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DOI: 10.1007/s12519-024-00854-7
Abstract: An increased number of double-negative T (DNT) cells expressing the αβ T cell receptor (αβ+DNT cells) is one of the diagnostic criteria for autoimmune lymphoproliferative syndrome (ALPS). Moreover, these cells are expanded in a widely… read more here.
Keywords: double negative; pediatric rheumatic; dnt cells; dnt ... See more keywords
Revisiting double-negative T cells in autoimmune lymphoproliferative immunodeficiencies: a case series.
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DOI: 10.15586/aei.v52i5.1115
Abstract: BACKGROUND Elevated level of double-negative T (DNT) cells is a historical hallmark of autoimmune lymphoproliferative syndrome (ALPS) diagnosis. However, the peripheral blood level of DNT cells might also be compromised in autoimmune lymphoproliferative immunodeficiencies (ALPID)… read more here.
Keywords: history; lymphoproliferative immunodeficiencies; double negative; dnt cells ... See more keywords
Ferroptosis and Dysfunction of CD3+CD4-CD8- T Cells are Associated with Poor Immune Reconstitution in HIV Patients.
Sign Up to like & getrecommendations! Published in 2025 at "Current HIV research"
DOI: 10.2174/011570162x366300250509112302
Abstract: INTRODUCTION Some HIV patients stay in an immune unresponsive state after antiretroviral therapy (ART), with a notably higher risk of AIDS-related and non-AIDS-related complications. Double-negative T cells (DNT) can compensate for immunity and prevent immune… read more here.
Keywords: hiv; function; dnt cells; ferroptosis ... See more keywords
Double-negative T Cells Inhibit Proliferation and Invasion of Human Pancreatic Cancer Cells in Co-culture
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DOI: 10.21873/anticanres.13795
Abstract: Background/Aim: Double-negative T (DNT) cells are phenotypically CD3+CD4−CD8−T cells. This study aimed to investigate the anti-cancer activity of DNT cells against pancreatic cancer cells. Materials and Methods: DNT cells were isolated from human peripheral blood.… read more here.
Keywords: invasion; pancreatic cancer; human pancreatic; dnt cells ... See more keywords
Decreased CD73+ Double-Negative T Cells and Elevated Level of Soluble CD73 Correlated With and Predicted Poor Immune Reconstitution in HIV-Infected Patients After Antiretroviral Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.869286
Abstract: Although extensive use of antiretroviral therapy (ART) has made great progress in controlling HIV replication and improving CD4+ T cell recovery, the immune reconstitution remained insufficient in some patients, who were defined as poor immunological… read more here.
Keywords: immune reconstitution; cd73; dnt cells; hiv ... See more keywords
Elevated Foxp3+ double-negative T cells are associated with disease progression during HIV infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.947647
Abstract: Persistent immune activation, which occurs during the whole course of HIV infection, plays a pivotal role in CD4+ T cells depletion and AIDS progression. Furthermore, immune activation is a key factor that leads to impaired… read more here.
Keywords: immune activation; dnt cells; hiv; hiv infection ... See more keywords