Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.02.021
Abstract: The Mec1 and Rad53 kinases play a central role during acute replication stress in budding yeast. They are also essential for viability in normal growth conditions, but the signal that activates the Mec1-Rad53 pathway in… read more here.
Keywords: phase; dntp; dna; dna replication ... See more keywords
Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.08.010
Abstract: Unlike HIV-1, HIV-2 and some SIV strains replicate at high dNTP concentrations even in macrophages due to their accessory proteins, Vpx or Vpr, that target SAMHD1 dNTPase for proteasomal degradation. We previously reported that HIV-1… read more here.
Keywords: dntp; reverse; conformational change; samhd1 non ... See more keywords
Chl1 helicase controls replication fork progression by regulating dNTP pools
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DOI: 10.26508/lsa.202101153
Abstract: Chl1 helicase affects RPA-dependent checkpoint activation after replication fork arrest by ensuring proper dNTP levels, thereby controlling replication fork progression under stress conditions. Eukaryotic cells have evolved a replication stress response that helps to overcome… read more here.
Keywords: replication fork; dntp; replication; fork progression ... See more keywords