Population Pharmacokinetic Models for Direct Oral Anticoagulants: A Systematic Review and Clinical Appraisal Using Exposure Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2649
Abstract: Available data have shown an association between direct oral anticoagulant (DOAC) plasma concentration and clinical, particularly bleeding, events. Factors that may influence DOAC plasma concentration are therefore the focus of particular attention. Population pharmacokinetic (PopPK)… read more here.
Keywords: plasma concentration; population pharmacokinetic; direct oral; doac plasma ... See more keywords
Impact of direct oral anticoagulant concentration on clinical outcomes in Asian patients with atrial fibrillation.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2927
Abstract: A real-world association between direct oral anticoagulant (DOAC) concentration and clinical outcomes among Asian patients with atrial fibrillation (AF) is reported herein. Patients with AF aged ≥20 years who used DOAC for ≥3 days were enrolled. Trough… read more here.
Keywords: clinical outcomes; oral anticoagulant; concentration; direct oral ... See more keywords
Concise Commentary: Whether and When to Resume Anticoagulation After Gastrointestinal Bleeding
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06323-1
Abstract: The timing of resuming oral anticoagulants after gastrointestinal bleeding (GIB) is still controversial in clinical practice due to the lack of evidence-based guideline recommendations. In this issue of the Digestive Diseases and Sciences, Tapaskar et… read more here.
Keywords: doac; gib; oral anticoagulants; resumption ... See more keywords
Appropriateness of direct oral anticoagulant dosing and its relation to drug levels in atrial fibrillation patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01815-y
Abstract: Direct oral anticoagulants (DOACs) are commonly administered at a level that is lower than that recommended by dose reduction criteria. This raises concern regarding the adequacy of anticoagulation achieved. To evaluate the relationship between inappropriate… read more here.
Keywords: atrial fibrillation; doac; drug levels; direct oral ... See more keywords
DOAC compared to LMWH in the treatment of cancer related-venous thromboembolism: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02055-1
Abstract: Low molecular weight heparins (LMWH) are the standard of care for the treatment of cancer-associated venous thromboembolism (CA-VTE). We performed a systematic review and meta-analysis to compare the effects of direct oral anticoagulants (DOAC) versus… read more here.
Keywords: doac; analysis; treatment; lmwh treatment ... See more keywords
Switching between direct oral anticoagulants: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02367-2
Abstract: Crossover between direct oral anticoagulants (DOACs) has been underinvestigated, but happens frequently in clinical practice. It is still unknown whether DOACs have similar rates of switch, or whether some DOACs are more prone to be… read more here.
Keywords: doac doac; doac; switch; doac switch ... See more keywords
Continuous and minimally-interrupted direct oral anticoagulant are both safe compared with vitamin K antagonist for atrial fibrillation ablation: An updated meta-analysis.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.03.095
Abstract: BACKGROUND The appropriate and safe peri-procedural anticoagulation schedule for patients on a direct oral anticoagulant (DOAC) undergoing AF ablation is not known. We aimed to evaluate the safety and efficacy of both continuous and minimally-interrupted… read more here.
Keywords: doac; continuous minimally; oral anticoagulant; ablation ... See more keywords
Influence of Direct Oral Anticoagulants on Rates of Oral Anticoagulation for Atrial Fibrillation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.03.540
Abstract: BACKGROUND Oral anticoagulation (OAC) with warfarin is underused for atrial fibrillation (AF). The availability of direct oral anticoagulants (DOACs) may improve overall OAC rates in AF patients, but a large-scale evaluation of their effects has… read more here.
Keywords: atrial fibrillation; doac; overall oac; use ... See more keywords
Quality of life after switching from well-controlled vitamin K antagonist to direct oral anticoagulant: Little to GAInN.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis research"
DOI: 10.1016/j.thromres.2020.04.007
Abstract: BACKGROUND Direct oral anticoagulants (DOAC) and vitamin K antagonists (VKA) prevent thromboembolism in atrial fibrillation (AF). DOAC have a fixed dosing regimen and obviate INR monitoring. Therefore, DOAC presumably affect quality of life (QoL) less… read more here.
Keywords: doac; well controlled; switching well; direct oral ... See more keywords
DOAC Dipstick testing can reliably exclude the presence of clinically relevant DOAC concentrations in circulation.
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1753-2748
Abstract: In certain clinical situations, it is necessary to determine whether clinically relevant plasma levels of direct oral anticoagulants (DOACs) are present. We examined whether qualitative testing of DOACs in urine samples can exclude DOAC plasma… read more here.
Keywords: doac dipstick; doac; plasma; dipstick testing ... See more keywords
Performance of a Qualitative Point-of-Care Strip Test to Detect DOAC Exposure at the Emergency Department: A Cohort-Type Cross-Sectional Diagnostic Accuracy Study
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/s-0042-1750327
Abstract: An accurate point-of-care test for detecting effective anticoagulation by direct oral anticoagulants (DOACs) in emergencies is an unmet need. We investigated the accuracy of a urinary qualitative strip test (DOAC Dipstick) to detect relevant DOAC… read more here.
Keywords: test; emergency department; doac exposure; doac ... See more keywords