Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2022.1292
Abstract: Importance Dose-reduced regimens of direct oral anticoagulants (DOACs) may be used for 2 main purposes: dose-adjusted treatment intended as full-intensity anticoagulation (eg, for stroke prevention in atrial fibrillation [AF] in patients requiring dose reduction) or… read more here.
Keywords: dose adjusted; low intensity; treatment; dose reduced ... See more keywords
Comparison of warfarin versus DOACs in patients with concomitant indication for oral anticoagulation undergoing TAVI; results from the ATLAS registry
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01968-w
Abstract: The optimal antithrombotic therapy for patients undergoing TAVI with concomitant indication for oral anticoagulation remains unclear. In this high-risk population group, there is a paucity of data with regards to the use of DOACs. In… read more here.
Keywords: anticoagulation; undergoing tavi; concomitant indication; indication oral ... See more keywords
Prescribing trends of oral anticoagulants in England over the last decade: a focus on new and old drugs and adverse events reporting
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-021-02416-4
Abstract: Direct-acting oral anticoagulants (DOACs) are replacing conventional VKA (vitamin K antagonist, i.e., warfarin) for various indications where a therapeutic anticoagulant effect is desired. We evaluated the prescribing patterns of the DOACs and warfarin, cost implications… read more here.
Keywords: oral anticoagulants; year; adverse events; prescribing trends ... See more keywords
Current status of oral anticoagulant adherence in Japanese patients with atrial fibrillation: A claims database analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiology"
DOI: 10.1016/j.jjcc.2021.02.007
Abstract: BACKGROUND Direct oral anticoagulants (DOACs) are widely used for stroke prevention in patients with non-valvular atrial fibrillation (NVAF). We investigated the adherence of DOACs for years known to be associated with the effectiveness in Japanese… read more here.
Keywords: atrial fibrillation; analysis; claims database; doacs ... See more keywords
Morbidity and mortality after fragility hip fracture surgery in patients receiving vitamin K antagonists and direct oral anticoagulants.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.04.022
Abstract: INTRODUCTION Early surgical treatment is recommended to reduce morbidity and mortality in patients with fragility hip fractures. Anticoagulation treatment poses a surgical challenge. While the action of vitamin K antagonists (VKAs) can be reversed, for… read more here.
Keywords: fragility hip; doacs; morbidity mortality; mortality ... See more keywords
Thromboprophylaxis for orthopedic surgery; An updated meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis research"
DOI: 10.1016/j.thromres.2020.12.007
Abstract: BACKGROUND Venous thromboembolism (VTE) is a serious complication of orthopedic surgery. Low molecular weight heparin (LMWH) has been the standard of care for thromboprophylaxis in this population. However, direct oral anticoagulants (DOACs) are increasingly being… read more here.
Keywords: orthopedic surgery; vte; surgery; thromboprophylaxis orthopedic ... See more keywords
Dose specific effectiveness and safety of DOACs in patients with non-valvular atrial fibrillation: A Canadian retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis research"
DOI: 10.1016/j.thromres.2021.05.005
Abstract: BACKGROUND Direct oral anticoagulants (DOACs) have been proven to be effective and safe for prevention of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF). However, suboptimal adherence, variable dosing and use… read more here.
Keywords: low dose; rivaroxaban; cohort; doacs ... See more keywords
The Efficacy and Safety of DOACs in Inherited Antithrombin Deficiency: A Cohort Study from a Tertiary Referral Center
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DOI: 10.1055/a-2379-7288
Abstract: Abstract Background  Individuals with inherited antithrombin deficiency (IATD) have a high risk of venous thromboembolism (VTE). Most VTEs are managed with direct oral anticoagulants (DOACs), but the utility of DOACs in antithrombin deficiency (ATD) is… read more here.
Keywords: doacs; inherited antithrombin; antithrombin deficiency; deficiency ... See more keywords
Current evidence on the use of direct oral anticoagulants in patients with myeloproliferative neoplasm: a systematic review
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2023.2174515
Abstract: ABSTRACT Introduction Thromboembolic events in myeloproliferative neoplasms (MPNs) are one of the most important causes of mortality and morbidity, in which vitamin K antagonists (VKAs) have been used mostly. Recently, direct oral anticoagulants (DOACs) are… read more here.
Keywords: review; systematic review; direct oral; oral anticoagulants ... See more keywords
Impact of different dose reduction criteria on dose assignment of current DOACs and related outcomes: an analysis from 4-year data of the ETNA-AF Europe programme
Sign Up to like & getrecommendations! Published in 2024 at "Europace"
DOI: 10.1093/europace/euae102.238
Abstract: Abstract Background Direct oral anticoagulants (DOACs) are the standard treatment for stroke prevention in patients with atrial fibrillation (AF). Pharmacological characteristics and dose reduction criteria of the four currently available DOACs are different. Several studies… read more here.
Keywords: doacs; history; reduction; dose reduction ... See more keywords
Factors influencing oral anticoagulant prescribing decisions for patients with atrial fibrillation: a systematic review of qualitative and quantitative evidence
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Pharmacy Practice"
DOI: 10.1093/ijpp/riab015.044
Abstract: Despite their efficacy in reducing stroke risk in patients with atrial fibrillation (AF), oral anticoagulants (OACs) remain under-prescribed [1]. Until recently, warfarin has been the dominant OAC. The introduction of direct oral anticoagulants (DOACs) led… read more here.
Keywords: doacs; review; health; choice ... See more keywords