Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2022.2055764
Abstract: ABSTRACT Background Hypertension is a major global health problem. It is a major risk factor of cardiovascular disease. One of the most used experimental models in studying antihypertensive action is the deoxycorticosterone acetate (DOCA)-salt hypertensive… read more here.
Keywords: hypertension; deoxycorticosterone acetate; salt induced; induced hypertension ... See more keywords
Preparation of poly-l-lysine-based nanoparticles with pH-sensitive release of curcumin for targeted imaging and therapy of liver cancer in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery"
DOI: 10.1080/10717544.2018.1461957
Abstract: Abstract Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer was compared to that of CUR solution in vitro and in… read more here.
Keywords: poly lysine; vitro vivo; cy5; release curcumin ... See more keywords
JK07 prevents atrial fibrosis and atrial fibrillation inducibility in a porcine DOCA model
Sign Up to like & getrecommendations! Published in 2023 at "Europace"
DOI: 10.1093/europace/euad122.065
Abstract: Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Geconcerteerde Onderzoeksactie (GOA) grant 499 of the University of Antwerp Industrieel OnderzoeksFonds/Strategisch Basisonderzoek 498 (IOF/SBO) research grant of the… read more here.
Keywords: atrial fibrosis; jk07; doca; doca veh ... See more keywords
A13768 Long term FTY720 treatment induced renal arteriole endothelial injury in deoxycorticosterone acetate (DOCA)/salt hypertensive rat
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548296.01877.d9
Abstract: Objectives: The sphingosine-1-phosphate (S1P) receptor modulator FTY720 exerts pleiotropic effects on the cardiovascular system. We examined the effects of long term FTY720 treatment on mineralocorticoid/salt-induced renal injury. Methods: Uninephrectomized rats on 0.9% NaCl/0.3% KCl drinking… read more here.
Keywords: fty720; doca fty720; doca; fty720 group ... See more keywords
Role of the median preoptic nucleus in the development of chronic DOCA-salt hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5719157
Abstract: Lesions of the anteroventral third ventricle (AV3V region) are known to prevent many forms of experimental hypertension, including mineralocorticoid (DOCA-salt) hypertension in the rat. However, AV3V lesions include the organum vasculosum of the lamina terminalis… read more here.
Keywords: hypertension; physiology; salt hypertension; doca ... See more keywords
IL-1R mediated renal sensory nerve activity drives hypertension in the DOCA-Salt mouse
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734346
Abstract: Clinical trials of renal denervation (RDN) have shown unanticipated changes in non-renal sympathetic activity. It has been hypothesized that this is due to ablation of sympathoexcitatory afferent renal nerves, which are overactive under conditions of… read more here.
Keywords: hypertension; ardn anakinra; physiology; doca ... See more keywords
Abstract P237: Ileal Content Cross Transplantation Between Ovlt Lesioned (ovltx) And Sham Rats Alters The Hypertensive Response In The Doca Salt Model
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hyp.76.suppl_1.p237
Abstract: Limited studies suggest a relationship between gut microbiome changes and specific types of hypertension. Using the deoxycorticosterone acetate (DOCA) salt model in rats, our lab previously demonstrated that the hypertensive response in DOCA-treated rats requires… read more here.
Keywords: doca salt; sham rats; ileal content; doca ... See more keywords
Multiple Sclerosis Drug Fingolimod Induces Thrombotic Microangiopathy in Deoxycorticosterone Acetate/Salt Hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.10655
Abstract: We examined whether fingolimod (FTY720), an S1PR (sphingosine-1-phosphate receptor) modulator, has beneficial or harmful effects on mineralocorticoid/salt-induced renal injury. Uninephrectomized rats on 0.9% NaCl/0.3% KCl drinking solution were randomly divided into control, control+FTY720, deoxycorticosterone acetate… read more here.
Keywords: doca fty720; doca; fty720 group; thrombotic microangiopathy ... See more keywords
Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice
Sign Up to like & getrecommendations! Published in 2020 at "BMC Nephrology"
DOI: 10.1186/s12882-020-01815-8
Abstract: Background Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2). SphK1/S1P pathway is implicated in the progression of chronic kidney disease. However, the role of SphK1/S1P pathway in… read more here.
Keywords: kidney damage; doca; doca salt; mice ... See more keywords
The Triad Na+ Activated Na+ Channel (Nax)—Salt Inducible KINASE (SIK) and (Na+ + K+)-ATPase: Targeting the Villains to Treat Salt Resistant and Sensitive Hypertension
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097887
Abstract: The Na+-activated Na+ channel (Nax) and salt-inducible kinase (SIK) are stimulated by increases in local Na+ concentration, affecting (Na+ + K+)-ATPase activity. To test the hypothesis that the triad Nax/SIK/(Na+ + K+)-ATPase contributes to kidney… read more here.
Keywords: kidney; activity; atpase; doca ... See more keywords