A13768 Long term FTY720 treatment induced renal arteriole endothelial injury in deoxycorticosterone acetate (DOCA)/salt hypertensive rat
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DOI: 10.1097/01.hjh.0000548296.01877.d9
Abstract: Objectives: The sphingosine-1-phosphate (S1P) receptor modulator FTY720 exerts pleiotropic effects on the cardiovascular system. We examined the effects of long term FTY720 treatment on mineralocorticoid/salt-induced renal injury. Methods: Uninephrectomized rats on 0.9% NaCl/0.3% KCl drinking… read more here.
Keywords: fty720; doca fty720; doca; fty720 group ... See more keywords
Multiple Sclerosis Drug Fingolimod Induces Thrombotic Microangiopathy in Deoxycorticosterone Acetate/Salt Hypertension
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DOI: 10.1161/hypertensionaha.117.10655
Abstract: We examined whether fingolimod (FTY720), an S1PR (sphingosine-1-phosphate receptor) modulator, has beneficial or harmful effects on mineralocorticoid/salt-induced renal injury. Uninephrectomized rats on 0.9% NaCl/0.3% KCl drinking solution were randomly divided into control, control+FTY720, deoxycorticosterone acetate… read more here.
Keywords: doca fty720; doca; fty720 group; thrombotic microangiopathy ... See more keywords