ROSTAFUROXIN AMELIORATES THE INWARD REMODELING AND STIFFNESS IN RESISTANCE ARTERIES FROM DEOXYCORTICOSTERONE ACETATE-SALT HYPERTENSIVE RATS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000539855.66619.e8
Abstract: Objective: We have shown that rostafuroxin (ROSTA), an antagonist of endogenous ouabain (OUA), block the biding of OUA to Na+ K+ -ATPase and inhibits the cSRC downstream activation in mesenteric resistance arteries (MRA), which ameliorates… read more here.
Keywords: inward remodeling; doca salt; salt rats; salt ... See more keywords
Collecting duct-specific knockout of sphingosine-1-phosphate receptor 1 aggravates DOCA-salt hypertension in mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002809
Abstract: Objective: We have previously reported that renal medullary sphingosine-1-phosphate (S1P) regulates sodium excretion via the S1P type-1 receptor (S1PR1). As S1PR1 is predominantly expressed in collecting ducts (CD), the present study tested the hypothesis that… read more here.
Keywords: mice; doca salt; sodium; salt ... See more keywords
Role of the median preoptic nucleus in the development of chronic DOCA-salt hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5719157
Abstract: Lesions of the anteroventral third ventricle (AV3V region) are known to prevent many forms of experimental hypertension, including mineralocorticoid (DOCA-salt) hypertension in the rat. However, AV3V lesions include the organum vasculosum of the lamina terminalis… read more here.
Keywords: hypertension; physiology; salt hypertension; doca ... See more keywords
Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates DOCA-salt-induced endothelial cell and arterial stiffening
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730293
Abstract: Introduction: Vascular stiffening is an independent predictor of cardiovascular diseases, the leading cause of death worldwide. High dietary salt intake has been shown to increase vascular stiffness in humans, especially in salt-sensitive populations. To date,… read more here.
Keywords: physiology; endothelial cell; mice; doca salt ... See more keywords
Sex differences in renal hemodynamics, autoregulation, and hypertensive injury in rats
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733137
Abstract: There is limited data on sex differences in renal hemodynamics and autoregulation (AR). We assessed renal vascular resistance (RVR) and renal AR in conscious male (M) and female (F) rats with intact kidneys, uninephrectomy (UNX),… read more here.
Keywords: hemodynamics; differences renal; physiology; sex ... See more keywords
IL-1R mediated renal sensory nerve activity drives hypertension in the DOCA-Salt mouse
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734346
Abstract: Clinical trials of renal denervation (RDN) have shown unanticipated changes in non-renal sympathetic activity. It has been hypothesized that this is due to ablation of sympathoexcitatory afferent renal nerves, which are overactive under conditions of… read more here.
Keywords: hypertension; ardn anakinra; physiology; doca ... See more keywords
Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000489757
Abstract: Background/Aims: Cardiac remodeling is a critical pathogenetic process leading to heart failure. Suppressor of cytokine signaling-3 (SOCS3) is demonstrated as a key negative regulator of the gp130 receptor to inhibit cardiac hypertrophy. However, the role… read more here.
Keywords: doca salt; socs3; salt induced; activation gp130 ... See more keywords
Antihypertensive and Renoprotective Effects of Dietary Flaxseed and its Mechanism of Action in Deoxycorticosterone Acetate-Salt Hypertensive Rats
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacology"
DOI: 10.1159/000502789
Abstract: Background/Aims: Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here, we examined the effects of flaxseed powder, which includes all flaxseed components, flaxseed oil, composed… read more here.
Keywords: doca salt; deoxycorticosterone acetate; antihypertensive renoprotective; salt ... See more keywords
Finerenone Reduces Renal RORγt γδ T Cells and Protects against Cardiorenal Damage
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Nephrology"
DOI: 10.1159/000524940
Abstract: Introduction: Chronic activation of the mineralocorticoid receptor (MR) leads to pathological processes like inflammation and fibrosis during cardiorenal disease. Modulation of immunological processes in the heart or kidney may serve as a mechanistic and therapeutic… read more here.
Keywords: ror; finerenone; renal ror; doca salt ... See more keywords
Abstract P2030: DOCA-Salt Diminishes Brain RAS Activity In Parallel With Plasma And Renal RAS Activity - No Evidence For Selective Brain RAS Activation
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2030
Abstract: Deoxycorticosterone acetate (DOCA)-salt is suggested to increase blood pressure via selective upregulation of the brain renin-angiotensin system (RAS), while suppressing the circulating RAS. Yet, we have observed parallel downregulation of plasma and brain renin in… read more here.
Keywords: doca salt; brain ras; agt; ang ... See more keywords
Abstract P237: Ileal Content Cross Transplantation Between Ovlt Lesioned (ovltx) And Sham Rats Alters The Hypertensive Response In The Doca Salt Model
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hyp.76.suppl_1.p237
Abstract: Limited studies suggest a relationship between gut microbiome changes and specific types of hypertension. Using the deoxycorticosterone acetate (DOCA) salt model in rats, our lab previously demonstrated that the hypertensive response in DOCA-treated rats requires… read more here.
Keywords: doca salt; sham rats; ileal content; doca ... See more keywords