DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114399
Abstract: Dedicator of cytokinesis 2 (DOCK2), an atypical Rac activator, has important anti-inflammatory properties in blepharitis, enteric bacterial infection and colitis. However, the roles of DOCK2in macrophage activation and acute lung injury(ALI) are still poorly elucidated.… read more here.
Keywords: dock2; mice; lung injury; injury ... See more keywords
Growth of B Cell Receptor Microclusters Is Regulated by PIP2 and PIP3 Equilibrium and Dock2 Recruitment and Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.117
Abstract: The growth of B cell receptor (BCR) microclusters upon antigen stimulation drives B cell activation. Here, we show that PI3K-mediated PIP3 production is required for the growth of BCR microclusters. This growth is likely inhibited… read more here.
Keywords: bcr; dock2; cell receptor; growth cell ... See more keywords
Dedicator of Cytokinesis 2 (DOCK2) Silencing Protects Against Cerebral Ischemia/Reperfusion by Modulating Microglia Polarization via the Activation of the STAT6 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2022.03.040
Abstract: Cerebral ischemia/reperfusion is the major pathophysiological process in stroke and could lead to severe and permanent disability. The current study aimed to investigate the effects of dedicator of cytokinesis 2 (DOCK2) on cerebral ischemia/reperfusion-induced cerebral… read more here.
Keywords: stat6; dock2; ischemia reperfusion; polarization ... See more keywords
Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aao4874
Abstract: A modified form of cholesterol protects the eye from immune cell invasion by inhibiting the Rac-specific GEF DOCK2. Evading the immune system with a lipid Some tissues, such as the eye, locally suppress immune cells… read more here.
Keywords: immune; dock2; cholesterol sulfate; cholesterol ... See more keywords
Insights from DOCK2 in cell function and pathophysiology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.997659
Abstract: Dedicator of cytokinesis 2 (DOCK2) can activate the downstream small G protein Rac and regulate cytoskeletal reorganization. DOCK2 is essential for critical physiological processes such as migration, activation, proliferation, and effects of immune cells, including… read more here.
Keywords: dock2 cell; cell function; development; insights dock2 ... See more keywords
DOCK2 Mutation and Recurrent Hemophagocytic Lymphohistiocytosis
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13020434
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome resulting from uncontrolled hyper-inflammation, excessive immune system activation, and elevated levels of inflammatory cytokines. HLH can be caused by the inability to downregulate activated macrophages by natural killer (NK)… read more here.
Keywords: hlh; dock2 mutation; hemophagocytic lymphohistiocytosis; dock2 ... See more keywords