P27 Successful treatment of severe eczema and plane warts with Dupilumab in a child with Dedicator of Cytokinesis 8 (DOCK8) deficiency (Autosomal recessive form of hyper-IgE syndrome)
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DOI: 10.1093/bjd/ljad483.035
Abstract: A six-year-old girl first presented with severe eczema at the age of 6 months, which was difficult to control with topical treatments. She was found to have severely elevated total IgE and multiple food allergies.… read more here.
Keywords: dock8; severe eczema; deficiency autosomal; dock8 deficiency ... See more keywords
Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency
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DOI: 10.1111/pai.13236
Abstract: Biallelic mutations in the dedicator of cytokinesis 8 gene (DOCK8) cause a progressive combined immunodeficiency (CID) characterized by susceptibility to severe viral skin infections, atopic diseases, recurrent respiratory infections, and malignancy. Hematopoietic stem cell transplantation… read more here.
Keywords: dock8 deficiency; dedicator cytokinesis; hsct; dock8 ... See more keywords
Successfully treated with siltuximab and prednisone in a 7-year-old girl with DOCK8-deficiency presenting as recurrent wart-like lesions: a case report
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DOI: 10.3389/fimmu.2024.1414573
Abstract: Dedicator of cytokinesis 8 (DOCK8) deficiency represents a primary immunodeficiency with a wide range of clinical symptoms, including recurrent infections, atopy, and increased malignancy risk. This study presents a case of a 6-year-old girl with… read more here.
Keywords: girl dock8; dock8 deficiency; old girl; deficiency ... See more keywords