Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.
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DOI: 10.1016/j.ejmech.2018.12.064
Abstract: The potential of specific proteasome inhibitors to act as anti-cancer agents has attracted intensive investigations. The proteasome can be covalently inhibited by epoxyketone derivatives via a two-step reaction. Several computational approaches have been developed to… read more here.
Keywords: docking modelling; proteasome inhibitors; proteasome; covalent docking ... See more keywords